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Perturbed states of the bacterial chromosome: a thymineless death case study

Overview of attention for article published in Frontiers in Microbiology, April 2015
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Title
Perturbed states of the bacterial chromosome: a thymineless death case study
Published in
Frontiers in Microbiology, April 2015
DOI 10.3389/fmicb.2015.00363
Pubmed ID
Authors

Lev Ostrer, Bree L Hamann, Arkady Khodursky

Abstract

Spatial patterns of transcriptional activity in the living genome of Escherichia coli represent one of the more peculiar aspects of the E. coli chromosome biology. Spatial transcriptional correlations can be observed throughout the chromosome, and their formation depends on the state of replication in the cell. The condition of thymine starvation leading to thymineless death (TLD) is at the "cross-roads" of replication and transcription. According to a current view, e.g., (Cagliero et al., 2014), one of the cellular objectives is to segregate the processes of transcription and replication in time and space. An ultimate segregation would take place when one process is inhibited and another is not, as it happens during thymine starvation, which results in numerous molecular and physiological abnormalities associated with TLD. One of such abnormalities is the loss of spatial correlations in the vicinity of the origin of replication. We review the transcriptional consequences of replication inhibition by thymine starvation in a context of the state of DNA template in the starved cells and opine about a possible significance of normal physiological coupling between the processes of replication and transcription.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 23%
Researcher 4 18%
Other 2 9%
Professor > Associate Professor 2 9%
Student > Bachelor 1 5%
Other 3 14%
Unknown 5 23%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 32%
Agricultural and Biological Sciences 6 27%
Computer Science 3 14%
Chemistry 1 5%
Engineering 1 5%
Other 0 0%
Unknown 4 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 May 2015.
All research outputs
#15,330,127
of 22,800,560 outputs
Outputs from Frontiers in Microbiology
#15,136
of 24,749 outputs
Outputs of similar age
#157,579
of 265,147 outputs
Outputs of similar age from Frontiers in Microbiology
#224
of 358 outputs
Altmetric has tracked 22,800,560 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 24,749 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,147 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 358 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.