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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Sub-MICs of Mentha piperita essential oil and menthol inhibits AHL mediated quorum sensing and biofilm of Gram-negative bacteria
|
|---|---|
| Published in |
Frontiers in Microbiology, May 2015
|
| DOI | 10.3389/fmicb.2015.00420 |
| Pubmed ID | |
| Authors |
Fohad M. Husain, Iqbal Ahmad, Mohammad S. Khan, Ejaz Ahmad, Qudisa Tahseen, Mohd Shahnawaz Khan, Nasser A. Alshabib |
| Abstract |
Bacterial quorum sensing (QS) is a density dependent communication system that regulates the expression of certain genes including production of virulence factors in many pathogens. Bioactive plant extract/compounds inhibiting QS regulated gene expression may be a potential candidate as antipathogenic drug. In this study anti-QS activity of peppermint (Mentha piperita) oil was first tested using the Chromobacterium violaceum CVO26 biosensor. Further, the findings of the present investigation revealed that peppermint oil (PMO) at sub-Minimum Inhibitory Concentrations (sub-MICs) strongly interfered with acyl homoserine lactone (AHL) regulated virulence factors and biofilm formation in Pseudomonas aeruginosa and Aeromonas hydrophila. The result of molecular docking analysis attributed the QS inhibitory activity exhibited by PMO to menthol. Assessment of ability of menthol to interfere with QS systems of various Gram-negative pathogens comprising diverse AHL molecules revealed that it reduced the AHL dependent production of violacein, virulence factors, and biofilm formation indicating broad-spectrum anti-QS activity. Using two Escherichia coli biosensors, MG4/pKDT17 and pEAL08-2, we also confirmed that menthol inhibited both the las and pqs QS systems. Further, findings of the in vivo studies with menthol on nematode model Caenorhabditis elegans showed significantly enhanced survival of the nematode. Our data identified menthol as a novel broad spectrum QS inhibitor. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 13% |
| United Kingdom | 1 | 13% |
| Switzerland | 1 | 13% |
| Unknown | 5 | 63% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 63% |
| Scientists | 2 | 25% |
| Science communicators (journalists, bloggers, editors) | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 199 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Ghana | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 196 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 41 | 21% |
| Student > Master | 27 | 14% |
| Researcher | 18 | 9% |
| Student > Doctoral Student | 15 | 8% |
| Student > Bachelor | 13 | 7% |
| Other | 33 | 17% |
| Unknown | 52 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 38 | 19% |
| Biochemistry, Genetics and Molecular Biology | 24 | 12% |
| Immunology and Microbiology | 24 | 12% |
| Medicine and Dentistry | 9 | 5% |
| Chemistry | 6 | 3% |
| Other | 23 | 12% |
| Unknown | 75 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 June 2015.
All research outputs
#6,872,615
of 24,901,761 outputs
Outputs from Frontiers in Microbiology
#6,632
of 28,458 outputs
Outputs of similar age
#75,078
of 269,789 outputs
Outputs of similar age from Frontiers in Microbiology
#80
of 379 outputs
Altmetric has tracked 24,901,761 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 28,458 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,789 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 379 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.