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X Demographics
Mendeley readers
Attention Score in Context
| Title |
MioC and GidA proteins promote cell division in E. coli
|
|---|---|
| Published in |
Frontiers in Microbiology, May 2015
|
| DOI | 10.3389/fmicb.2015.00516 |
| Pubmed ID | |
| Authors |
Mark Lies, Bryan J. Visser, Mohan C. Joshi, David Magnan, David Bates |
| Abstract |
The well-conserved genes surrounding the E. coli replication origin, mioC and gidA, do not normally affect chromosome replication and have little known function. We report that mioC and gidA mutants exhibit a moderate cell division inhibition phenotype. Cell elongation is exacerbated by a fis deletion, likely owing to delayed replication and subsequent cell cycle stress. Measurements of replication initiation frequency and origin segregation indicate that mioC and gidA do not inhibit cell division through any effect on oriC function. Division inhibition is also independent of the two known replication/cell division checkpoints, SOS and nucleoid occlusion. Complementation analysis indicates that mioC and gidA affect cell division in trans, indicating their effect is at the protein level. Transcriptome analysis by RNA sequencing showed that expression of a cell division septum component, YmgF, is significantly altered in mioC and gidA mutants. Our data reveal new roles for the gene products of gidA and mioC in the division apparatus, and we propose that their expression, cyclically regulated by chromatin remodeling at oriC, is part of a cell cycle regulatory program coordinating replication initiation and cell division. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 33% |
| Switzerland | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 57 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 32% |
| Researcher | 9 | 16% |
| Student > Bachelor | 8 | 14% |
| Professor > Associate Professor | 5 | 9% |
| Student > Doctoral Student | 4 | 7% |
| Other | 5 | 9% |
| Unknown | 8 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 20 | 35% |
| Agricultural and Biological Sciences | 17 | 30% |
| Immunology and Microbiology | 6 | 11% |
| Physics and Astronomy | 2 | 4% |
| Environmental Science | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 9 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 June 2015.
All research outputs
#14,226,014
of 22,807,037 outputs
Outputs from Frontiers in Microbiology
#12,398
of 24,760 outputs
Outputs of similar age
#138,309
of 266,679 outputs
Outputs of similar age from Frontiers in Microbiology
#180
of 387 outputs
Altmetric has tracked 22,807,037 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 24,760 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,679 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 387 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.