Title |
Role of gut microbiota in the modulation of atherosclerosis-associated immune response
|
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Published in |
Frontiers in Microbiology, June 2015
|
DOI | 10.3389/fmicb.2015.00671 |
Pubmed ID | |
Authors |
Dmitry A. Chistiakov, Yuri V. Bobryshev, Emil Kozarov, Igor A. Sobenin, Alexander N. Orekhov |
Abstract |
Inflammation and metabolic abnormalities are linked to each other. At present, pathogenic inflammatory response was recognized as a major player in metabolic diseases. In humans, intestinal microflora could significantly influence the development of metabolic diseases including atherosclerosis. Commensal bacteria were shown to activate inflammatory pathways through altering lipid metabolism in adipocytes, macrophages, and vascular cells, inducing insulin resistance, and producing trimethylamine-N-oxide. However, gut microbiota could also play the atheroprotective role associated with anthocyanin metabolism and administration of probiotics and their components. Here, we review the mechanisms by which the gut microbiota may influence atherogenesis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 17% |
Venezuela, Bolivarian Republic of | 1 | 8% |
Canada | 1 | 8% |
Australia | 1 | 8% |
Netherlands | 1 | 8% |
Switzerland | 1 | 8% |
Unknown | 5 | 42% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 9 | 75% |
Scientists | 2 | 17% |
Practitioners (doctors, other healthcare professionals) | 1 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | <1% |
Bosnia and Herzegovina | 1 | <1% |
Italy | 1 | <1% |
Unknown | 158 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 34 | 21% |
Researcher | 25 | 16% |
Student > Doctoral Student | 15 | 9% |
Student > Bachelor | 14 | 9% |
Student > Master | 12 | 7% |
Other | 34 | 21% |
Unknown | 27 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 35 | 22% |
Agricultural and Biological Sciences | 31 | 19% |
Medicine and Dentistry | 28 | 17% |
Immunology and Microbiology | 11 | 7% |
Nursing and Health Professions | 6 | 4% |
Other | 13 | 8% |
Unknown | 37 | 23% |