Title |
Vitamin D receptor and epigenetics in HIV infection and drug abuse
|
---|---|
Published in |
Frontiers in Microbiology, August 2015
|
DOI | 10.3389/fmicb.2015.00788 |
Pubmed ID | |
Authors |
Nirupama Chandel, Ashwani Malhotra, Pravin C. Singhal |
Abstract |
Illicit drug abuse is highly prevalent and serves as a powerful co-factor for HIV exacerbation. Epigenetic alterations in drug abuse and HIV infection determine expression of several critical genes such as vitamin D receptor (VDR), which participates in proliferation, differentiation, cell death under both physiological and pathological conditions. On that account, active vitamin D, the ligand of VDR, is used as an adjuvant therapy to control infection, slow down progression of chronic kidney diseases, and cancer chemotherapy. Interestingly, vitamin D may not be able to augment VDR expression optimally in several instances where epigenetic contributes to down regulation of VDR; however, reversal of epigenetic corruption either by demethylating agents (DACs) or histone deacetylase (HDAC) inhibitors would be able to maximize expression of VDR in these instances. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 33% |
France | 1 | 17% |
Switzerland | 1 | 17% |
Unknown | 2 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 83% |
Scientists | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 7 | 23% |
Other | 3 | 10% |
Student > Doctoral Student | 3 | 10% |
Student > Ph. D. Student | 3 | 10% |
Student > Bachelor | 2 | 6% |
Other | 7 | 23% |
Unknown | 6 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 8 | 26% |
Biochemistry, Genetics and Molecular Biology | 4 | 13% |
Agricultural and Biological Sciences | 4 | 13% |
Immunology and Microbiology | 3 | 10% |
Nursing and Health Professions | 1 | 3% |
Other | 5 | 16% |
Unknown | 6 | 19% |