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Analysis of the Bacillus cereus SpoIIS antitoxin-toxin system reveals its three-component nature

Overview of attention for article published in Frontiers in Microbiology, August 2015
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Title
Analysis of the Bacillus cereus SpoIIS antitoxin-toxin system reveals its three-component nature
Published in
Frontiers in Microbiology, August 2015
DOI 10.3389/fmicb.2015.00808
Pubmed ID
Authors

Jana Melničáková, Zuzana Bečárová, Jana Makroczyová, Imrich Barák

Abstract

Programmed cell death in bacteria is generally associated with two-component toxin-antitoxin systems. The SpoIIS toxin-antitoxin system, consisting of a membrane-bound SpoIISA toxin and a small, cytosolic antitoxin SpoIISB, was originally identified in Bacillus subtilis. In this work we describe the Bacillus cereus SpoIIS system which is a three-component system, harboring an additional gene spoIISC. Its protein product serves as an antitoxin, and similarly as SpoIISB, is able to bind SpoIISA and abolish its toxic effect. Our results indicate that SpoIISC seems to be present not only in B. cereus but also in other Bacilli containing a SpoIIS toxin-antitoxin system. In addition, we show that B. cereus SpoIISA can form higher oligomers and we discuss the possible role of this multimerization for the protein's toxic function.

X Demographics

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Malaysia 1 3%
Slovakia 1 3%
Unknown 28 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 23%
Student > Master 7 23%
Student > Bachelor 5 17%
Researcher 4 13%
Professor 1 3%
Other 3 10%
Unknown 3 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 43%
Biochemistry, Genetics and Molecular Biology 8 27%
Immunology and Microbiology 3 10%
Unspecified 1 3%
Medicine and Dentistry 1 3%
Other 1 3%
Unknown 3 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 August 2015.
All research outputs
#15,342,608
of 22,821,814 outputs
Outputs from Frontiers in Microbiology
#15,151
of 24,775 outputs
Outputs of similar age
#154,536
of 264,036 outputs
Outputs of similar age from Frontiers in Microbiology
#218
of 357 outputs
Altmetric has tracked 22,821,814 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 24,775 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,036 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 357 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.