Title |
Respiratory virus modulation of host nucleocytoplasmic transport; target for therapeutic intervention?
|
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Published in |
Frontiers in Microbiology, August 2015
|
DOI | 10.3389/fmicb.2015.00848 |
Pubmed ID | |
Authors |
Leon Caly, Reena Ghildyal, David A. Jans |
Abstract |
The respiratory diseases caused by rhinovirus, respiratory syncytial virus, and influenza virus represent a large social and financial burden on healthcare worldwide. Although all three viruses have distinctly unique properties in terms of infection and replication, they share the ability to exploit/manipulate the host-cell nucleocytoplasmic transport system in order to replicate effectively and efficiently. This review outlines the various ways in which infection by these viruses impacts on the host nucleocytoplasmic transport system, and examples where inhibition thereof in turn decreases viral replication. The highly conserved nature of the nucleocytoplasmic transport system and the viral proteins that interact with it make this virus-host interface a prime candidate for the development of specific antiviral therapeutics in the future. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 34 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 7 | 21% |
Student > Master | 6 | 18% |
Student > Doctoral Student | 4 | 12% |
Student > Ph. D. Student | 4 | 12% |
Researcher | 3 | 9% |
Other | 5 | 15% |
Unknown | 5 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 8 | 24% |
Biochemistry, Genetics and Molecular Biology | 7 | 21% |
Medicine and Dentistry | 5 | 15% |
Immunology and Microbiology | 4 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Other | 1 | 3% |
Unknown | 7 | 21% |