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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Inside the Envelope: Endogenous Retrovirus-K Env as a Biomarker and Therapeutic Target
|
|---|---|
| Published in |
Frontiers in Microbiology, November 2015
|
| DOI | 10.3389/fmicb.2015.01244 |
| Pubmed ID | |
| Authors |
Marie-Josée Nadeau, Mamneet Manghera, Renée N. Douville |
| Abstract |
Due to multiple ancestral human retroviral germ cell infections, the modern human genome is strewn with relics of these infections, termed endogenous retroviruses (ERVs). ERV expression has been silenced due to negative selective pressures and genetic phenomena such as mutations and epigenetic silencing. Nonetheless, select ERVs have retained the capacity to be damaging to their host when reawakened. Much of the current research on the ERVK Env protein strongly suggests a causal or contributive role in the pathogenesis of various cancers, autoimmune and infectious diseases. Additionally, there is a small body of research suggesting that ERVK Env has been domesticated for use in placental development, akin to the ERVW syncytin. Though much is left to ascertain, the innate immune response to ERVK Env expression has been partially characterized and appears to be due to a region located in the transmembrane domain of the Env protein. In this review, we aim to highlight ERVK Env as a biomarker for inflammatory conditions and explore its use as a future therapeutic target for cancers, HIV infection and neurological disease. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| France | 1 | 1% |
| Belgium | 1 | 1% |
| Unknown | 73 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 25% |
| Researcher | 18 | 24% |
| Student > Master | 8 | 11% |
| Student > Bachelor | 8 | 11% |
| Student > Doctoral Student | 4 | 5% |
| Other | 12 | 16% |
| Unknown | 7 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 24 | 32% |
| Biochemistry, Genetics and Molecular Biology | 19 | 25% |
| Immunology and Microbiology | 12 | 16% |
| Medicine and Dentistry | 6 | 8% |
| Computer Science | 3 | 4% |
| Other | 3 | 4% |
| Unknown | 9 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 December 2015.
All research outputs
#16,237,186
of 25,654,806 outputs
Outputs from Frontiers in Microbiology
#14,185
of 29,651 outputs
Outputs of similar age
#156,084
of 292,892 outputs
Outputs of similar age from Frontiers in Microbiology
#213
of 433 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 29,651 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 292,892 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 433 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.