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Bacterial Vaginosis Biofilms: Challenges to Current Therapies and Emerging Solutions

Overview of attention for article published in Frontiers in Microbiology, January 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

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5 news outlets
blogs
1 blog
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9 X users
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1 research highlight platform

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305 Mendeley
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Title
Bacterial Vaginosis Biofilms: Challenges to Current Therapies and Emerging Solutions
Published in
Frontiers in Microbiology, January 2016
DOI 10.3389/fmicb.2015.01528
Pubmed ID
Authors

Daniela Machado, Joana Castro, Ana Palmeira-de-Oliveira, José Martinez-de-Oliveira, Nuno Cerca

Abstract

Bacterial vaginosis (BV) is the most common genital tract infection in women during their reproductive years and it has been associated with serious health complications, such as preterm delivery and acquisition or transmission of several sexually transmitted agents. BV is characterized by a reduction of beneficial lactobacilli and a significant increase in number of anaerobic bacteria, including Gardnerella vaginalis, Atopobium vaginae, Mobiluncus spp., Bacteroides spp. and Prevotella spp.. Being polymicrobial in nature, BV etiology remains unclear. However, it is certain that BV involves the presence of a thick vaginal multi-species biofilm, where G. vaginalis is the predominant species. Similar to what happens in many other biofilm-related infections, standard antibiotics, like metronidazole, are unable to fully eradicate the vaginal biofilm, which can explain the high recurrence rates of BV. Furthermore, antibiotic therapy can also cause a negative impact on the healthy vaginal microflora. These issues sparked the interest in developing alternative therapeutic strategies. This review provides a quick synopsis of the currently approved and available antibiotics for BV treatment while presenting an overview of novel strategies that are being explored for the treatment of this disorder, with special focus on natural compounds that are able to overcome biofilm-associated antibiotic resistance.

X Demographics

X Demographics

The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 305 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 <1%
Slovenia 1 <1%
South Africa 1 <1%
Unknown 302 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 42 14%
Student > Bachelor 37 12%
Researcher 36 12%
Student > Ph. D. Student 35 11%
Other 19 6%
Other 51 17%
Unknown 85 28%
Readers by discipline Count As %
Medicine and Dentistry 54 18%
Agricultural and Biological Sciences 39 13%
Immunology and Microbiology 31 10%
Biochemistry, Genetics and Molecular Biology 29 10%
Pharmacology, Toxicology and Pharmaceutical Science 19 6%
Other 41 13%
Unknown 92 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 57. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2023.
All research outputs
#750,726
of 25,443,857 outputs
Outputs from Frontiers in Microbiology
#416
of 29,374 outputs
Outputs of similar age
#13,469
of 403,768 outputs
Outputs of similar age from Frontiers in Microbiology
#11
of 474 outputs
Altmetric has tracked 25,443,857 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 29,374 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 403,768 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 474 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.