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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Impact of Resistance to Fluconazole on Virulence and Morphological Aspects of Cryptococcus neoformans and Cryptococcus gattii Isolates
|
|---|---|
| Published in |
Frontiers in Microbiology, February 2016
|
| DOI | 10.3389/fmicb.2016.00153 |
| Pubmed ID | |
| Authors |
Suélen A. Rossi, Nuria Trevijano-Contador, Liliana Scorzoni, Ana Cecilia Mesa-Arango, Haroldo C. de Oliveira, Karin Werther, Tânia de Freitas Raso, Maria J. S. Mendes-Giannini, Oscar Zaragoza, Ana M. Fusco-Almeida |
| Abstract |
Cryptococcus sp. are responsible for around 1 million cases of meningitis every year. Fluconazole (FLU) is commonly used in the treatment of cryptococcosis, mainly in immunocompromised patients and the resistance is usually reported after long periods of treatment. In this study, the morphological characterization and virulence profile of FLU-susceptible and FLU-resistant clinical and environmental isolates of C. neoformans and C. gattii were performed both in vitro and in vivo using the Galleria mellonella model. FLU-susceptible isolates from C. neoformans were significantly more virulent than the FLU-resistant isolates. FLU-susceptible C. gattii isolates showed a different virulence profile from C. neoformans isolates where only the environmental isolate, CL, was more virulent compared with the resistant isolates. Cell morphology and capsule size were analyzed and the FLU-resistant isolates did not change significantly compared with the most sensitive isolates. Growth at 37°C was also evaluated and in both species, the resistant isolates showed a reduced growth at this temperature, indicating that FLU resistance can affect their growth. Based on the results obtained is possible suggest that FLU resistance can influence the morphology of the isolates and consequently changed the virulence profiles. The most evident results were observed for C. neoformans showing that the adaptation of isolates to antifungal selective pressure influenced the loss of virulence. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 33% |
| India | 1 | 33% |
| Switzerland | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 67% |
| Members of the public | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | 3% |
| Unknown | 61 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 17 | 27% |
| Student > Ph. D. Student | 11 | 17% |
| Student > Bachelor | 8 | 13% |
| Student > Postgraduate | 6 | 10% |
| Researcher | 6 | 10% |
| Other | 7 | 11% |
| Unknown | 8 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 17 | 27% |
| Biochemistry, Genetics and Molecular Biology | 11 | 17% |
| Immunology and Microbiology | 9 | 14% |
| Medicine and Dentistry | 8 | 13% |
| Business, Management and Accounting | 1 | 2% |
| Other | 5 | 8% |
| Unknown | 12 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 February 2016.
All research outputs
#14,708,659
of 22,849,304 outputs
Outputs from Frontiers in Microbiology
#13,629
of 24,849 outputs
Outputs of similar age
#164,536
of 297,534 outputs
Outputs of similar age from Frontiers in Microbiology
#310
of 535 outputs
Altmetric has tracked 22,849,304 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 24,849 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 297,534 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 535 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.