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Bacterial Glycosyltransferases: Challenges and Opportunities of a Highly Diverse Enzyme Class Toward Tailoring Natural Products

Overview of attention for article published in Frontiers in Microbiology, February 2016
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234 Mendeley
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Title
Bacterial Glycosyltransferases: Challenges and Opportunities of a Highly Diverse Enzyme Class Toward Tailoring Natural Products
Published in
Frontiers in Microbiology, February 2016
DOI 10.3389/fmicb.2016.00182
Pubmed ID
Authors

Jochen Schmid, Dominik Heider, Norma J. Wendel, Nadine Sperl, Volker Sieber

Abstract

The enzyme subclass of glycosyltransferases (GTs; EC 2.4) currently comprises 97 families as specified by CAZy classification. One of their important roles is in the biosynthesis of disaccharides, oligosaccharides, and polysaccharides by catalyzing the transfer of sugar moieties from activated donor molecules to other sugar molecules. In addition GTs also catalyze the transfer of sugar moieties onto aglycons, which is of great relevance for the synthesis of many high value natural products. Bacterial GTs show a higher sequence similarity in comparison to mammalian ones. Even when most GTs are poorly explored, state of the art technologies, such as protein engineering, domain swapping or computational analysis strongly enhance our understanding and utilization of these very promising classes of proteins. This perspective article will focus on bacterial GTs, especially on classification, screening and engineering strategies to alter substrate specificity. The future development in these fields as well as obstacles and challenges will be highlighted and discussed.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 234 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 <1%
Unknown 233 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 54 23%
Student > Master 35 15%
Researcher 30 13%
Student > Bachelor 20 9%
Student > Doctoral Student 16 7%
Other 26 11%
Unknown 53 23%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 68 29%
Agricultural and Biological Sciences 43 18%
Chemistry 25 11%
Immunology and Microbiology 11 5%
Chemical Engineering 5 2%
Other 19 8%
Unknown 63 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2016.
All research outputs
#13,967,666
of 22,849,304 outputs
Outputs from Frontiers in Microbiology
#11,436
of 24,853 outputs
Outputs of similar age
#151,005
of 298,010 outputs
Outputs of similar age from Frontiers in Microbiology
#269
of 535 outputs
Altmetric has tracked 22,849,304 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 24,853 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 298,010 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 535 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.