Title |
Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health
|
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Published in |
Frontiers in Microbiology, February 2016
|
DOI | 10.3389/fmicb.2016.00185 |
Pubmed ID | |
Authors |
David Ríos-Covián, Patricia Ruas-Madiedo, Abelardo Margolles, Miguel Gueimonde, Clara G. de los Reyes-Gavilán, Nuria Salazar |
Abstract |
The colon is inhabited by a dense population of microorganisms, the so-called "gut microbiota," able to ferment carbohydrates and proteins that escape absorption in the small intestine during digestion. This microbiota produces a wide range of metabolites, including short chain fatty acids (SCFA). These compounds are absorbed in the large bowel and are defined as 1-6 carbon volatile fatty acids which can present straight or branched-chain conformation. Their production is influenced by the pattern of food intake and diet-mediated changes in the gut microbiota. SCFA have distinct physiological effects: they contribute to shaping the gut environment, influence the physiology of the colon, they can be used as energy sources by host cells and the intestinal microbiota and they also participate in different host-signaling mechanisms. We summarize the current knowledge about the production of SCFA, including bacterial cross-feedings interactions, and the biological properties of these metabolites with impact on the human health. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 12 | 24% |
United Kingdom | 6 | 12% |
Spain | 4 | 8% |
Canada | 3 | 6% |
Ireland | 2 | 4% |
France | 2 | 4% |
Denmark | 1 | 2% |
Australia | 1 | 2% |
Switzerland | 1 | 2% |
Other | 1 | 2% |
Unknown | 17 | 34% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 28 | 56% |
Practitioners (doctors, other healthcare professionals) | 16 | 32% |
Scientists | 6 | 12% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | <1% |
Ireland | 1 | <1% |
South Africa | 1 | <1% |
Brazil | 1 | <1% |
Spain | 1 | <1% |
United Kingdom | 1 | <1% |
Unknown | 1992 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 314 | 16% |
Student > Master | 298 | 15% |
Student > Bachelor | 277 | 14% |
Researcher | 228 | 11% |
Student > Doctoral Student | 106 | 5% |
Other | 292 | 15% |
Unknown | 484 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 403 | 20% |
Biochemistry, Genetics and Molecular Biology | 295 | 15% |
Medicine and Dentistry | 179 | 9% |
Immunology and Microbiology | 161 | 8% |
Nursing and Health Professions | 101 | 5% |
Other | 277 | 14% |
Unknown | 583 | 29% |