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Role of Trypanosoma cruzi Trans-sialidase on the Escape from Host Immune Surveillance

Overview of attention for article published in Frontiers in Microbiology, March 2016
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Title
Role of Trypanosoma cruzi Trans-sialidase on the Escape from Host Immune Surveillance
Published in
Frontiers in Microbiology, March 2016
DOI 10.3389/fmicb.2016.00348
Pubmed ID
Authors

Ana F. F. R. Nardy, Celio G. Freire-de-Lima, Ana R. Pérez, Alexandre Morrot

Abstract

Chagas disease is caused by the flagellate protozoan Trypanosoma cruzi, affecting millions of people throughout Latin America. The parasite dampens host immune response causing modifications in diverse lymphoid compartments, including the thymus. T. cruzi trans-sialidase (TS) seems to play a fundamental role in such immunopathological events. This unusual enzyme catalyses the transference of sialic acid molecules from host glycoconjugates to acceptor molecules placed on the parasite surface. TS activity mediates several biological effects leading to the subversion of host immune system, hence favoring both parasite survival and the establishment of chronic infection. This review summarizes current findings on the roles of TS in the immune response during T. cruzi infection.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 199 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
United States 1 <1%
Argentina 1 <1%
Brazil 1 <1%
Unknown 195 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 38 19%
Student > Master 30 15%
Researcher 23 12%
Student > Ph. D. Student 22 11%
Student > Doctoral Student 17 9%
Other 29 15%
Unknown 40 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 62 31%
Agricultural and Biological Sciences 29 15%
Immunology and Microbiology 27 14%
Medicine and Dentistry 12 6%
Chemistry 7 4%
Other 19 10%
Unknown 43 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 March 2016.
All research outputs
#20,315,221
of 22,856,968 outputs
Outputs from Frontiers in Microbiology
#22,466
of 24,866 outputs
Outputs of similar age
#254,704
of 300,567 outputs
Outputs of similar age from Frontiers in Microbiology
#479
of 555 outputs
Altmetric has tracked 22,856,968 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 24,866 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 300,567 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 555 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.