Title |
Induced Bacterial Cross-Resistance toward Host Antimicrobial Peptides: A Worrying Phenomenon
|
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Published in |
Frontiers in Microbiology, March 2016
|
DOI | 10.3389/fmicb.2016.00381 |
Pubmed ID | |
Authors |
Osmel Fleitas, Octávio L. Franco |
Abstract |
Bacterial resistance to conventional antibiotics has reached alarming levels, threatening to return to the pre-antibiotic era. Therefore, the search for new antimicrobial compounds that overcome the resistance phenomenon has become a priority. Antimicrobial peptides (AMPs) appear as one of the most promising antibiotic medicines. However, in recent years several AMP-resistance mechanisms have been described. Moreover, the AMP-resistance phenomenon has become more complex due to its association with cross-resistance toward AMP effectors of the host innate immune system. In this context, the use of AMPs as a therapeutic option could be potentially hazardous, since bacteria could develop resistance toward our innate immune system. Here, we review the findings of major studies that deal with the AMP cross-resistance phenomenon. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 5 | 42% |
Netherlands | 2 | 17% |
Curaçao | 1 | 8% |
Canada | 1 | 8% |
Switzerland | 1 | 8% |
Unknown | 2 | 17% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 50% |
Scientists | 5 | 42% |
Practitioners (doctors, other healthcare professionals) | 1 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 1% |
Unknown | 86 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 18 | 21% |
Student > Bachelor | 18 | 21% |
Student > Master | 14 | 16% |
Researcher | 11 | 13% |
Student > Doctoral Student | 4 | 5% |
Other | 9 | 10% |
Unknown | 13 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 20 | 23% |
Agricultural and Biological Sciences | 18 | 21% |
Immunology and Microbiology | 15 | 17% |
Medicine and Dentistry | 4 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
Other | 10 | 11% |
Unknown | 17 | 20% |