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Update on Pyrin Functions and Mechanisms of Familial Mediterranean Fever

Overview of attention for article published in Frontiers in Microbiology, March 2016
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4 X users

Citations

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73 Dimensions

Readers on

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103 Mendeley
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Title
Update on Pyrin Functions and Mechanisms of Familial Mediterranean Fever
Published in
Frontiers in Microbiology, March 2016
DOI 10.3389/fmicb.2016.00456
Pubmed ID
Authors

Gayane Manukyan, Rustam Aminov

Abstract

Mutations in the MEFV gene, which encodes the protein named pyrin (also called marenostrin or TRIM20), are associated with the autoinflammatory disease familial Mediterranean fever (FMF). Recent genetic and immunologic studies uncovered novel functions of pyrin and raised several new questions in relation to FMF pathogenesis. The disease is clinically heterogeneous reflecting the complexity and multiplicity of pyrin functions. The main functions uncovered so far include its involvement in innate immune response such as the inflammasome assemblage and, as a part of the inflammasome, sensing intracellular danger signals, activation of mediators of inflammation, and resolution of inflammation by the autophagy of regulators of innate immunity. Based on these functions, the FMF-associated versions of pyrin confer a heightened sensitivity to a variety of intracellular danger signals and postpone the resolution of innate immune responses. It remains to be demonstrated, however, what kind of selective advantage the heterozygous carriage conferred in the past to be positively selected and maintained in populations from the Mediterranean basin.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 103 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 <1%
Unknown 102 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 17%
Student > Master 14 14%
Researcher 12 12%
Other 10 10%
Student > Bachelor 9 9%
Other 19 18%
Unknown 21 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 26 25%
Medicine and Dentistry 23 22%
Agricultural and Biological Sciences 13 13%
Immunology and Microbiology 8 8%
Nursing and Health Professions 2 2%
Other 6 6%
Unknown 25 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 August 2020.
All research outputs
#15,041,990
of 25,182,110 outputs
Outputs from Frontiers in Microbiology
#12,083
of 28,877 outputs
Outputs of similar age
#154,494
of 307,251 outputs
Outputs of similar age from Frontiers in Microbiology
#268
of 544 outputs
Altmetric has tracked 25,182,110 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 28,877 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 307,251 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 544 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.