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Comparison between Immunization Routes of Live Attenuated Salmonella Typhimurium Strains Expressing BCSP31, Omp3b, and SOD of Brucella abortus in Murine Model

Overview of attention for article published in Frontiers in Microbiology, April 2016
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Title
Comparison between Immunization Routes of Live Attenuated Salmonella Typhimurium Strains Expressing BCSP31, Omp3b, and SOD of Brucella abortus in Murine Model
Published in
Frontiers in Microbiology, April 2016
DOI 10.3389/fmicb.2016.00550
Pubmed ID
Authors

Won K. Kim, Ja Y. Moon, Suk Kim, Jin Hur

Abstract

Live, attenuated Salmonella Typhimurium vaccine candidate expressing BCSP31, Omp3b, and SOD proteins of Brucella abortus was constructed. Thirty BALB/c mice were divided equally into three groups, Group A, were intraperitoneally (IP) inoculated with 100 μl of approximately 1.2 × 10(6) colony-forming units (CFUs)/ml of the Salmonella containing vector only in 100 μl as a control. And groups B and C mice were orally and IP immunized with approximately 1.2 × 10(9) CFU/ml of the mixture of three delivery strains in 10 μl and IP immunized with approximately 1.2 × 10(6) CFU/ml of the mixture in 100 μl, respectively. The serum IgG, TNF-α and IFN-γ concentrations in groups B (except Omp3b) and C were significantly higher than those in group A. Following challenge with B. abortus strain 544; challenge strain was detected <10(3) CFU from the spleen of all mice of group C. These results suggest that IP immunization with the mixture of the vaccine candidate can induce immune responses, and can effectively protect mice against brucellosis.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 29%
Student > Ph. D. Student 3 14%
Student > Doctoral Student 2 10%
Student > Bachelor 2 10%
Professor > Associate Professor 2 10%
Other 2 10%
Unknown 4 19%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 7 33%
Agricultural and Biological Sciences 4 19%
Immunology and Microbiology 4 19%
Nursing and Health Professions 1 5%
Biochemistry, Genetics and Molecular Biology 1 5%
Other 1 5%
Unknown 3 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2016.
All research outputs
#20,322,106
of 22,865,319 outputs
Outputs from Frontiers in Microbiology
#22,474
of 24,875 outputs
Outputs of similar age
#253,570
of 299,364 outputs
Outputs of similar age from Frontiers in Microbiology
#468
of 555 outputs
Altmetric has tracked 22,865,319 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 24,875 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 555 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.