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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Antimicrobial Activity and Phytochemical Analysis of Organic Extracts from Cleome spinosa Jaqc.
|
|---|---|
| Published in |
Frontiers in Microbiology, June 2016
|
| DOI | 10.3389/fmicb.2016.00963 |
| Pubmed ID | |
| Authors |
Ana P. Sant'Anna da Silva, Luís C. Nascimento da Silva, Caíque S. Martins da Fonseca, Janete M. de Araújo, Maria T. dos Santos Correia, Marilene da Silva Cavalcanti, Vera L. de Menezes Lima |
| Abstract |
Due to the use of Cleome spinosa Jacq. (Cleomaceae) in traditional medicine against inflammatory and infectious processes, this study evaluated the in vitro antimicrobial potential and phytochemical composition of extracts from its roots and leaves. From leaves (L) and roots (R) of C. spinosa different extracts were obtained (cyclohexane: ChL and ChR; chloroform: CL and CR; ethyl acetate: EAL and EAR, methanol: ML and MR). The antimicrobial activity was evaluated by the broth microdilution method to obtain the minimum inhibitory (MIC) and microbicidal (MMC) concentrations against 17 species, including bacteria and yeasts. Additionally, antimicrobial and combinatory effects with oxacillin were assessed against eight clinical isolates of Staphylococcus aureus. All C. spinosa extracts showed a broad spectrum of antimicrobial activity, as they have inhibited all tested bacteria and yeasts. This activity seems to be related to the phytochemicals (flavonoid, terpenoids and saponins) detected into the extracts of C. spinosa. ChL and CL extracts were the most actives, with MIC less than 1 mg/mL against S. aureus, Bacillus subtilis, and Micrococcus luteus. It is important to note that these concentrations are much lower than their 50% hemolysis concentration (HC50) values. Strong correlations were found between the average MIC against S. aureus and their phenolic (r = -0.89) and flavonoid content (r = -0.87), reinforcing the possible role of these metabolite classes on the antimicrobial activity of C. spinosa derived extracts. Moreover, CL and CR showed the best inhibitory activity against S. aureus clinical isolates, they also showed synergistic action with oxacillin against all these strains (at least at one combined proportion). These results encourage the identification of active substances which could be used as lead(s) molecules in the development of new antimicrobial drugs. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 125 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Indonesia | 1 | <1% |
| Nepal | 1 | <1% |
| India | 1 | <1% |
| Unknown | 122 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 24 | 19% |
| Student > Bachelor | 11 | 9% |
| Student > Ph. D. Student | 10 | 8% |
| Researcher | 5 | 4% |
| Student > Doctoral Student | 5 | 4% |
| Other | 18 | 14% |
| Unknown | 52 | 42% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 14% |
| Biochemistry, Genetics and Molecular Biology | 13 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 8% |
| Immunology and Microbiology | 6 | 5% |
| Medicine and Dentistry | 5 | 4% |
| Other | 13 | 10% |
| Unknown | 60 | 48% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2016.
All research outputs
#18,466,238
of 22,881,154 outputs
Outputs from Frontiers in Microbiology
#19,388
of 24,911 outputs
Outputs of similar age
#267,047
of 351,559 outputs
Outputs of similar age from Frontiers in Microbiology
#388
of 514 outputs
Altmetric has tracked 22,881,154 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 24,911 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 351,559 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 514 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.