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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Development of a Phage Cocktail to Control Proteus mirabilis Catheter-associated Urinary Tract Infections
|
|---|---|
| Published in |
Frontiers in Microbiology, June 2016
|
| DOI | 10.3389/fmicb.2016.01024 |
| Pubmed ID | |
| Authors |
Luís D. R. Melo, Patrícia Veiga, Nuno Cerca, Andrew M. Kropinski, Carina Almeida, Joana Azeredo, Sanna Sillankorva |
| Abstract |
Proteus mirabilis is an enterobacterium that causes catheter-associated urinary tract infections (CAUTIs) due to its ability to colonize and form crystalline biofilms on the catheters surface. CAUTIs are very difficult to treat, since biofilm structures are highly tolerant to antibiotics. Phages have been used widely to control a diversity of bacterial species, however, a limited number of phages for P. mirabilis have been isolated and studied. Here we report the isolation of two novel virulent phages, the podovirus vB_PmiP_5460 and the myovirus vB_PmiM_5461, which are able to target, respectively, 16 of the 26 and all the Proteus strains tested in this study. Both phages have been characterized thoroughly and sequencing data revealed no traces of genes associated with lysogeny. To further evaluate the phages' ability to prevent catheter's colonization by Proteus, the phages adherence to silicone surfaces was assessed. Further tests in phage-coated catheters using a dynamic biofilm model simulating CAUTIs, have shown a significant reduction of P. mirabilis biofilm formation up to 168 h of catheterization. These results highlight the potential usefulness of the two isolated phages for the prevention of surface colonization by this bacterium. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 178 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 178 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 28 | 16% |
| Student > Ph. D. Student | 27 | 15% |
| Student > Master | 27 | 15% |
| Researcher | 19 | 11% |
| Student > Doctoral Student | 10 | 6% |
| Other | 19 | 11% |
| Unknown | 48 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 34 | 19% |
| Biochemistry, Genetics and Molecular Biology | 24 | 13% |
| Agricultural and Biological Sciences | 15 | 8% |
| Medicine and Dentistry | 13 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 5% |
| Other | 28 | 16% |
| Unknown | 55 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2016.
All research outputs
#18,466,238
of 22,881,154 outputs
Outputs from Frontiers in Microbiology
#19,388
of 24,911 outputs
Outputs of similar age
#267,047
of 351,559 outputs
Outputs of similar age from Frontiers in Microbiology
#388
of 514 outputs
Altmetric has tracked 22,881,154 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 24,911 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 351,559 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 514 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.