Title |
A Review of SHV Extended-Spectrum β-Lactamases: Neglected Yet Ubiquitous
|
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Published in |
Frontiers in Microbiology, September 2016
|
DOI | 10.3389/fmicb.2016.01374 |
Pubmed ID | |
Authors |
Apostolos Liakopoulos, Dik Mevius, Daniela Ceccarelli |
Abstract |
β-lactamases are the primary cause of resistance to β-lactams among members of the family Enterobacteriaceae. SHV enzymes have emerged in Enterobacteriaceae causing infections in health care in the last decades of the Twentieth century, and they are now observed in isolates in different epidemiological settings both in human, animal and the environment. Likely originated from a chromosomal penicillinase of Klebsiella pneumoniae, SHV β-lactamases currently encompass a large number of allelic variants including extended-spectrum β-lactamases (ESBL), non-ESBL and several not classified variants. SHV enzymes have evolved from a narrow- to an extended-spectrum of hydrolyzing activity, including monobactams and carbapenems, as a result of amino acid changes that altered the configuration around the active site of the β -lactamases. SHV-ESBLs are usually encoded by self-transmissible plasmids that frequently carry resistance genes to other drug classes and have become widespread throughout the world in several Enterobacteriaceae, emphasizing their clinical significance. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Australia | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | <1% |
Unknown | 491 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 71 | 14% |
Student > Ph. D. Student | 60 | 12% |
Student > Bachelor | 59 | 12% |
Researcher | 53 | 11% |
Student > Doctoral Student | 24 | 5% |
Other | 62 | 13% |
Unknown | 163 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 86 | 17% |
Immunology and Microbiology | 69 | 14% |
Agricultural and Biological Sciences | 52 | 11% |
Medicine and Dentistry | 34 | 7% |
Veterinary Science and Veterinary Medicine | 25 | 5% |
Other | 49 | 10% |
Unknown | 177 | 36% |