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Brucella abortus Strain 2308 Wisconsin Genome: Importance of the Definition of Reference Strains

Overview of attention for article published in Frontiers in Microbiology, September 2016
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Title
Brucella abortus Strain 2308 Wisconsin Genome: Importance of the Definition of Reference Strains
Published in
Frontiers in Microbiology, September 2016
DOI 10.3389/fmicb.2016.01557
Pubmed ID
Authors

Marcela Suárez-Esquivel, Nazareth Ruiz-Villalobos, Amanda Castillo-Zeledón, César Jiménez-Rojas, R. Martin Roop, Diego J. Comerci, Elías Barquero-Calvo, Carlos Chacón-Díaz, Clayton C. Caswell, Kate S. Baker, Esteban Chaves-Olarte, Nicholas R. Thomson, Edgardo Moreno, Jean J. Letesson, Xavier De Bolle, Caterina Guzmán-Verri

Abstract

Brucellosis is a bacterial infectious disease affecting a wide range of mammals and a neglected zoonosis caused by species of the genetically homogenous genus Brucella. As in most studies on bacterial diseases, research in brucellosis is carried out by using reference strains as canonical models to understand the mechanisms underlying host pathogen interactions. We performed whole genome sequencing analysis of the reference strain B. abortus 2308 routinely used in our laboratory, including manual curated annotation accessible as an editable version through a link at https://en.wikipedia.org/wiki/Brucella#Genomics. Comparison of this genome with two publically available 2308 genomes showed significant differences, particularly indels related to insertional elements, suggesting variability related to the transposition of these elements within the same strain. Considering the outcome of high resolution genomic techniques in the bacteriology field, the conventional concept of strain definition needs to be revised.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 57 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 19%
Researcher 7 12%
Student > Doctoral Student 7 12%
Student > Master 6 10%
Professor 6 10%
Other 11 19%
Unknown 10 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 22%
Biochemistry, Genetics and Molecular Biology 11 19%
Immunology and Microbiology 11 19%
Veterinary Science and Veterinary Medicine 8 14%
Medicine and Dentistry 2 3%
Other 3 5%
Unknown 10 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 October 2016.
All research outputs
#20,344,065
of 22,890,496 outputs
Outputs from Frontiers in Microbiology
#22,535
of 24,938 outputs
Outputs of similar age
#279,777
of 322,600 outputs
Outputs of similar age from Frontiers in Microbiology
#345
of 436 outputs
Altmetric has tracked 22,890,496 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 24,938 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,600 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 436 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.