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Attention Score in Context
| Title |
High Prevalence of β-lactamase and Plasmid-Mediated Quinolone Resistance Genes in Extended-Spectrum Cephalosporin-Resistant Escherichia coli from Dogs in Shaanxi, China
|
|---|---|
| Published in |
Frontiers in Microbiology, November 2016
|
| DOI | 10.3389/fmicb.2016.01843 |
| Pubmed ID | |
| Authors |
Xiaoqiang Liu, Haixia Liu, Yinqian Li, Caiju Hao |
| Abstract |
Objective: The aim of this study was to investigate the occurrence and molecular characterization of extended-spectrum β-lactamases (ESBL), plasmid-mediated AmpC β-lactamase (pAmpC) and carbapenemases as well as plasmid-mediated quinolone-resistant (PMQR) among extended-spectrum cephalosporin-resistant (ESC-R) Escherichia coli from dogs in Shaanxi province in China. Methods: A total of 40 ESC-R Escherichia coli selected from 165 Extraintestinal pathogenic E. coli (ExPEC) isolated from dogs were screened and characterized for the genes encoding for the ESBLs, pAmpC, carbapenemases and PMQR genes by PCR and sequencing. Phylogenetic groups, virulence gene profiles and multilocus sequence typing (MLST) were used to investigate the genetic background of the ESC-R E. coli isolates. Results: Among 40 ESC-R E. coli, the predominant β-lactamase gene was blaCTX-Ms (n = 35), and followed by blaTEM-1 (n = 31), blaSHV-12 (n = 14), blaOXA-48 (n = 8), blaTEM-30 (n = 4), blaCMY-2 (n = 3) and blaDHA-1 (n = 2). The most common specific blaCTX-M gene subtype was blaCTX-M-15 (n = 31), and followed by blaCTX-M-123 (n = 14), blaCTX-M-1 (n = 10), blaCTX-M-14 (n = 10) and blaCTX-M-9 (n = 7). PMQR genes were detected in 32 (80%) isolates, and the predominant PMQR gene was aac(6')-Ib-cr (n = 26), followed by qnrS (n = 12), qnrD (n = 9), qnrB (n = 8), qepA (n = 4), and all PMQR genes were detected in co-existence with β-lactamase genes. traT (n = 34) and fimH (n = 32) were the most prevalent virulence genes, and virulence genes fimH, iutA, fyuA, malX, iha, and sat were more prevalent in phylogenetic group B2. The 40 ESC-R isolates analyzed were assigned to 22 sequence types (STs), and the clonal lineages ST131 (n = 10) and ST10 (n = 9) were the predominant STs. Conclusion: High prevalence of β-lantamases and PMQR genes were detected among ESC-R E. coli from companion animals. This is also the first description of the co-existence of six β-lantamase genes and five PMQR genes in one E. coli isolate. Moreover, 10 ST131 clones harboring CTX-M-15 were detected. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 59 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 17% |
| Student > Ph. D. Student | 6 | 10% |
| Student > Doctoral Student | 5 | 8% |
| Student > Bachelor | 5 | 8% |
| Student > Postgraduate | 5 | 8% |
| Other | 8 | 14% |
| Unknown | 20 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Veterinary Science and Veterinary Medicine | 8 | 14% |
| Immunology and Microbiology | 8 | 14% |
| Biochemistry, Genetics and Molecular Biology | 7 | 12% |
| Agricultural and Biological Sciences | 5 | 8% |
| Medicine and Dentistry | 4 | 7% |
| Other | 6 | 10% |
| Unknown | 21 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 November 2016.
All research outputs
#18,482,034
of 22,901,818 outputs
Outputs from Frontiers in Microbiology
#19,409
of 24,953 outputs
Outputs of similar age
#203,906
of 270,398 outputs
Outputs of similar age from Frontiers in Microbiology
#313
of 421 outputs
Altmetric has tracked 22,901,818 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 24,953 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
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We're also able to compare this research output to 421 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.