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Phenylpyrroles: 30 Years, Two Molecules and (Nearly) No Resistance

Overview of attention for article published in Frontiers in Microbiology, December 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • Good Attention Score compared to outputs of the same age and source (67th percentile)

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Title
Phenylpyrroles: 30 Years, Two Molecules and (Nearly) No Resistance
Published in
Frontiers in Microbiology, December 2016
DOI 10.3389/fmicb.2016.02014
Pubmed ID
Authors

Jaafar Kilani, Sabine Fillinger

Abstract

Phenylpyrroles are chemical analogs of the natural antifungal compound pyrrolnitrin. Fenpiclonil, but mainly fludioxonil are registered against multiple fungal crop diseases since over 25 years for seed or foliar treatment. They have severe physiological impacts on the pathogen, including membrane hyperpolarization, changes in carbon metabolism and the accumulation of metabolites leading to hyphal swelling and burst. The selection and characterization of mutants resistant to phenylpyrroles have revealed that these fungicides activate the fungal osmotic signal transduction pathway through their perception by a typical fungal hybrid histidine kinase (HHK). The HHK is prone to point mutations that confer fungicide resistance and affect its sensor domain, composed of tandem repeats of HAMP motifs. Fludioxonil resistant mutants have been selected in many fungal species under laboratory conditions. Generally they present severe impacts on fitness parameters. Since only few cases of field resistance specific to phenylpyrroles have been reported one may suspect that the fitness penalty of phenylpyrrole resistance is the reason for the lack of field resistance.

X Demographics

X Demographics

The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Indonesia 1 1%
Brazil 1 1%
Unknown 86 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 16%
Student > Master 13 15%
Researcher 11 13%
Student > Doctoral Student 8 9%
Student > Bachelor 8 9%
Other 11 13%
Unknown 23 26%
Readers by discipline Count As %
Agricultural and Biological Sciences 31 35%
Biochemistry, Genetics and Molecular Biology 11 13%
Chemistry 5 6%
Immunology and Microbiology 3 3%
Pharmacology, Toxicology and Pharmaceutical Science 3 3%
Other 9 10%
Unknown 26 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 February 2017.
All research outputs
#4,164,529
of 22,908,162 outputs
Outputs from Frontiers in Microbiology
#4,225
of 24,956 outputs
Outputs of similar age
#82,322
of 420,952 outputs
Outputs of similar age from Frontiers in Microbiology
#124
of 382 outputs
Altmetric has tracked 22,908,162 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 24,956 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 420,952 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 382 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.