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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Mechanisms Underlying T Cell Immunosenescence: Aging and Cytomegalovirus Infection
|
|---|---|
| Published in |
Frontiers in Microbiology, December 2016
|
| DOI | 10.3389/fmicb.2016.02111 |
| Pubmed ID | |
| Authors |
Wenjuan Tu, Sudha Rao |
| Abstract |
The ability of the human immune system to protect against infectious disease declines with age and efficacy of vaccination reduces significantly in the elderly. Aging of the immune system, also termed as immunosenescence, involves many changes in human T cell immunity that is characterized by a loss in naïve T cell population and an increase in highly differentiated CD28- memory T cell subset. There is extensive data showing that latent persistent human cytomegalovirus (HCMV) infection is also associated with age-related immune dysfunction in the T cells, which might enhance immunosenescence. Understanding the molecular mechanisms underlying age-related and HCMV-related immunosenescence is critical for the development of effective age-targeted vaccines and immunotherapies. In this review, we will address the role of both aging and HCMV infection that contribute to the T cell senescence and discuss the potential molecular mechanisms in aged T cells. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 33% |
| Poland | 1 | 17% |
| Czechia | 1 | 17% |
| Australia | 1 | 17% |
| Unknown | 1 | 17% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 83% |
| Scientists | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 190 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | <1% |
| Unknown | 189 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 35 | 18% |
| Student > Master | 27 | 14% |
| Researcher | 22 | 12% |
| Student > Bachelor | 22 | 12% |
| Student > Doctoral Student | 16 | 8% |
| Other | 25 | 13% |
| Unknown | 43 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 40 | 21% |
| Immunology and Microbiology | 34 | 18% |
| Biochemistry, Genetics and Molecular Biology | 21 | 11% |
| Agricultural and Biological Sciences | 21 | 11% |
| Engineering | 7 | 4% |
| Other | 22 | 12% |
| Unknown | 45 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 38. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 February 2022.
All research outputs
#922,205
of 23,053,169 outputs
Outputs from Frontiers in Microbiology
#472
of 25,200 outputs
Outputs of similar age
#21,280
of 421,804 outputs
Outputs of similar age from Frontiers in Microbiology
#16
of 399 outputs
Altmetric has tracked 23,053,169 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 25,200 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,804 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 399 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.