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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Different Pathways Leading to Integrase Inhibitors Resistance
|
|---|---|
| Published in |
Frontiers in Microbiology, January 2017
|
| DOI | 10.3389/fmicb.2016.02165 |
| Pubmed ID | |
| Authors |
Eloïse Thierry, Eric Deprez, Olivier Delelis |
| Abstract |
Integrase strand-transfer inhibitors (INSTIs), such as raltegravir (RAL), elvitegravir, or dolutegravir (DTG), are efficient antiretroviral agents used in HIV treatment in order to inhibit retroviral integration. By contrast to RAL treatments leading to well-identified mutation resistance pathways at the integrase level, recent clinical studies report several cases of patients failing DTG treatment without clearly identified resistance mutation in the integrase gene raising questions for the mechanism behind the resistance. These compounds, by impairing the integration of HIV-1 viral DNA into the host DNA, lead to an accumulation of unintegrated circular viral DNA forms. This viral DNA could be at the origin of the INSTI resistance by two different ways. The first one, sustained by a recent report, involves 2-long terminal repeat circles integration and the second one involves expression of accumulated unintegrated viral DNA leading to a basal production of viral particles maintaining the viral information. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 83 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 19% |
| Student > Master | 14 | 17% |
| Student > Bachelor | 11 | 13% |
| Researcher | 8 | 10% |
| Student > Doctoral Student | 4 | 5% |
| Other | 11 | 13% |
| Unknown | 19 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 19% |
| Biochemistry, Genetics and Molecular Biology | 14 | 17% |
| Immunology and Microbiology | 9 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 6% |
| Agricultural and Biological Sciences | 5 | 6% |
| Other | 6 | 7% |
| Unknown | 28 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 December 2023.
All research outputs
#6,752,294
of 25,367,237 outputs
Outputs from Frontiers in Microbiology
#6,307
of 29,278 outputs
Outputs of similar age
#115,936
of 423,583 outputs
Outputs of similar age from Frontiers in Microbiology
#164
of 397 outputs
Altmetric has tracked 25,367,237 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 29,278 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 423,583 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 397 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.