Title |
The Potential of Systems Biology to Discover Antibacterial Mechanisms of Plant Phenolics
|
---|---|
Published in |
Frontiers in Microbiology, March 2017
|
DOI | 10.3389/fmicb.2017.00422 |
Pubmed ID | |
Authors |
Caroline S. Rempe, Kellie P. Burris, Scott C. Lenaghan, C. Neal Stewart |
Abstract |
Drug resistance of bacterial pathogens is a growing problem that can be addressed through the discovery of compounds with novel mechanisms of antibacterial activity. Natural products, including plant phenolic compounds, are one source of diverse chemical structures that could inhibit bacteria through novel mechanisms. However, evaluating novel antibacterial mechanisms of action can be difficult and is uncommon in assessments of plant phenolic compounds. With systems biology approaches, though, antibacterial mechanisms can be assessed without the bias of target-directed bioassays to enable the discovery of novel mechanism(s) of action against drug resistant microorganisms. This review article summarizes the current knowledge of antibacterial mechanisms of action of plant phenolic compounds and discusses relevant methodology. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 25% |
Spain | 2 | 25% |
United States | 1 | 13% |
Unknown | 3 | 38% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 50% |
Scientists | 4 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 150 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 20 | 13% |
Student > Master | 18 | 12% |
Researcher | 16 | 11% |
Student > Doctoral Student | 15 | 10% |
Student > Ph. D. Student | 11 | 7% |
Other | 27 | 18% |
Unknown | 43 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 22 | 15% |
Biochemistry, Genetics and Molecular Biology | 16 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 15 | 10% |
Medicine and Dentistry | 11 | 7% |
Immunology and Microbiology | 8 | 5% |
Other | 23 | 15% |
Unknown | 55 | 37% |