Title |
InlL from Listeria monocytogenes Is Involved in Biofilm Formation and Adhesion to Mucin
|
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Published in |
Frontiers in Microbiology, April 2017
|
DOI | 10.3389/fmicb.2017.00660 |
Pubmed ID | |
Authors |
Magdalena Popowska, Agata Krawczyk-Balska, Rafał Ostrowski, Mickaël Desvaux |
Abstract |
The bacterial etiological agent of listeriosis, Listeria monocytogenes, is an opportunistic intracellular foodborne pathogen. The infection cycle of L. monocytogenes is well-characterized and involves several key virulence factors, including internalins A and B. While 35 genes encoding internalins have been identified in L. monocytogenes, less than half of them have been characterized as yet. Focusing on lmo2026, it was shown this gene encodes a class I internalin, InlL, exhibiting domains potentially involved in adhesion. Following a functional genetic approach, InlL was demonstrated to be involved in initial bacterial adhesion as well as sessile development in L. monocytogenes. In addition, InlL enables binding to mucin of type 2, i.e., the main secreted mucin making up the mucus layer, rather than to surface-located mucin of type 1. InlL thus appears as a new molecular determinant contributing to the colonization ability of L. monocytogenes. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 73 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 13 | 18% |
Researcher | 12 | 16% |
Student > Master | 6 | 8% |
Other | 5 | 7% |
Student > Bachelor | 4 | 5% |
Other | 11 | 15% |
Unknown | 22 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 22 | 30% |
Biochemistry, Genetics and Molecular Biology | 11 | 15% |
Immunology and Microbiology | 7 | 10% |
Veterinary Science and Veterinary Medicine | 3 | 4% |
Computer Science | 1 | 1% |
Other | 3 | 4% |
Unknown | 26 | 36% |