Title |
Viruses and miRNAs: More Friends than Foes
|
---|---|
Published in |
Frontiers in Microbiology, May 2017
|
DOI | 10.3389/fmicb.2017.00824 |
Pubmed ID | |
Authors |
Patrice Bruscella, Silvia Bottini, Camille Baudesson, Jean-Michel Pawlotsky, Cyrille Feray, Michele Trabucchi |
Abstract |
There is evidence that eukaryotic miRNAs (hereafter called host miRNAs) play a role in the replication and propagation of viruses. Expression or targeting of host miRNAs can be involved in cellular antiviral responses. Most times host miRNAs play a role in viral life-cycles and promote infection through complex regulatory pathways. miRNAs can also be encoded by a viral genome and be expressed in the host cell. Viral miRNAs can share common sequences with host miRNAs or have totally different sequences. They can regulate a variety of biological processes involved in viral infection, including apoptosis, evasion of the immune response, or modulation of viral life-cycle phases. Overall, virus/miRNA pathway interaction is defined by a plethora of complex mechanisms, though not yet fully understood. This article review summarizes recent advances and novel biological concepts related to the understanding of miRNA expression, control and function during viral infections. The article also discusses potential therapeutic applications of this particular host-pathogen interaction. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 2 | 40% |
India | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 60% |
Scientists | 2 | 40% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 173 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 30 | 17% |
Student > Master | 23 | 13% |
Student > Bachelor | 21 | 12% |
Researcher | 19 | 11% |
Student > Doctoral Student | 14 | 8% |
Other | 18 | 10% |
Unknown | 48 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 51 | 29% |
Agricultural and Biological Sciences | 25 | 14% |
Immunology and Microbiology | 19 | 11% |
Medicine and Dentistry | 7 | 4% |
Computer Science | 2 | 1% |
Other | 11 | 6% |
Unknown | 58 | 34% |