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Clostridium chauvoei, an Evolutionary Dead-End Pathogen

Overview of attention for article published in Frontiers in Microbiology, June 2017
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • High Attention Score compared to outputs of the same age and source (89th percentile)

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2 blogs
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31 Dimensions

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Title
Clostridium chauvoei, an Evolutionary Dead-End Pathogen
Published in
Frontiers in Microbiology, June 2017
DOI 10.3389/fmicb.2017.01054
Pubmed ID
Authors

Lorenz Rychener, Saria In-Albon, Steven P. Djordjevic, Piklu Roy Chowdhury, Pamela Nicholson, Rosangela E. Ziech, Agueda C. de Vargas, Joachim Frey, Laurent Falquet

Abstract

Full genome sequences of 20 strains of Clostridium chauvoei, the etiological agent of blackleg of cattle and sheep, isolated from four different continents over a period of 64 years (1951-2015) were determined and analyzed. The study reveals that the genome of the species C. chauvoei is highly homogeneous compared to the closely related species C. perfringens, a widespread pathogen that affects human and many animal species. Analysis of the CRISPR locus is sufficient to differentiate most C. chauvoei strains and is the most heterogenous region in the genome, containing in total 187 different spacer elements that are distributed as 30 - 77 copies in the various strains. Some genetic differences are found in the 3 allelic variants of fliC1, fliC2 and fliC3 genes that encode structural flagellin proteins, and certain strains do only contain one or two alleles. However, the major virulence genes including the highly toxic C.chauvoei toxin A, the sialidase and the two hyaluronidases are fully conserved as are the metabolic and structural genes of C. chauvoei. These data indicate that C. chauvoei is a strict ruminant-associated pathogen that has reached a dead end in its evolution.

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X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 55 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 11 20%
Researcher 8 15%
Student > Ph. D. Student 6 11%
Student > Postgraduate 4 7%
Student > Master 4 7%
Other 8 15%
Unknown 14 25%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 12 22%
Agricultural and Biological Sciences 11 20%
Biochemistry, Genetics and Molecular Biology 7 13%
Immunology and Microbiology 3 5%
Nursing and Health Professions 1 2%
Other 2 4%
Unknown 19 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 February 2020.
All research outputs
#1,906,460
of 22,979,862 outputs
Outputs from Frontiers in Microbiology
#1,363
of 25,038 outputs
Outputs of similar age
#39,304
of 317,132 outputs
Outputs of similar age from Frontiers in Microbiology
#56
of 523 outputs
Altmetric has tracked 22,979,862 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 25,038 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,132 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 523 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.