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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Candida albicans: The Ability to Invade Epithelial Cells and Survive under Oxidative Stress Is Unlinked to Hyphal Length
|
|---|---|
| Published in |
Frontiers in Microbiology, July 2017
|
| DOI | 10.3389/fmicb.2017.01235 |
| Pubmed ID | |
| Authors |
Paloma K. Maza, Alexis Bonfim-Melo, Ana C. B. Padovan, Renato A. Mortara, Cristina M. Orikaza, Lilian M. Damas Ramos, Tauany R. Moura, Frederico M. Soriani, Ricardo S. Almeida, Erika Suzuki, Diana Bahia |
| Abstract |
In its hyphal form, Candida albicans invades epithelial and endothelial cells by two distinct mechanisms: active penetration and induced endocytosis. The latter is dependent on a reorganization of the host cytoskeleton (actin/cortactin recruitment), whilst active penetration does not rely on the host's cellular machinery. The first obstacle for the fungus to reach deep tissues is the epithelial barrier and this interaction is crucial for commensal growth, fungal pathogenicity and host defense. This study aimed to characterize in vitro epithelial HeLa cell invasion by four different isolates of C. albicans with distinct clinical backgrounds, including a C. albicans SC5314 reference strain. All isolates invaded HeLa cells, recruited actin and cortactin, and induced the phosphorylation of both Src-family kinases (SFK) and cortactin. Curiously, L3881 isolated from blood culture of a patient exhibited the highest resistance to oxidative stress, although this isolate showed reduced hyphal length and displayed the lowest cell damage and invasion rates. Collectively, these data suggest that the ability of C. albicans to invade HeLa cells, and to reach and adapt to the host's blood, including resistance to oxidative stress, may be independent of hyphal length. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 102 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 17% |
| Student > Bachelor | 14 | 14% |
| Student > Master | 12 | 12% |
| Professor | 3 | 3% |
| Researcher | 3 | 3% |
| Other | 8 | 8% |
| Unknown | 45 | 44% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 16 | 16% |
| Biochemistry, Genetics and Molecular Biology | 14 | 14% |
| Agricultural and Biological Sciences | 14 | 14% |
| Chemistry | 3 | 3% |
| Medicine and Dentistry | 2 | 2% |
| Other | 5 | 5% |
| Unknown | 48 | 47% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 July 2017.
All research outputs
#15,469,838
of 22,988,380 outputs
Outputs from Frontiers in Microbiology
#15,305
of 25,055 outputs
Outputs of similar age
#178,855
of 283,559 outputs
Outputs of similar age from Frontiers in Microbiology
#357
of 530 outputs
Altmetric has tracked 22,988,380 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 25,055 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 283,559 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 530 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.