You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Antiviral Properties of the Natural Polyphenols Delphinidin and Epigallocatechin Gallate against the Flaviviruses West Nile Virus, Zika Virus, and Dengue Virus
|
|---|---|
| Published in |
Frontiers in Microbiology, July 2017
|
| DOI | 10.3389/fmicb.2017.01314 |
| Pubmed ID | |
| Authors |
Ángela Vázquez-Calvo, Nereida Jiménez de Oya, Miguel A. Martín-Acebes, Emilia Garcia-Moruno, Juan-Carlos Saiz |
| Abstract |
The Flavivirus genus contains important pathogens, such as West Nile virus (WNV), Zika virus (ZIKV), and Dengue virus (DENV), which are enveloped plus-strand RNA viruses transmitted by mosquitoes and constitute a worrisome threat to global human and animal health. Currently no licensed drugs against them are available, being, thus, still necessary the search for effective antiviral molecules. In this line, a novel antiviral approach (economical, simple to use, and environmental friendly) is the use of natural compounds. Consequently, we have tested the antiviral potential of different polyphenols present in plants and natural products, such as wine and tea, against WNV, ZIKV, and DENV. So that, we assayed the effect of a panel of structurally related polyphenols [delphinidin (D), cyanidin (Cy), catechin (C), epicatechin (EC), epigallocatechin (EGC), and epigallocatechin gallate (EGCG)] on WNV infection, and found that D and EGCG inhibited more effectively the virus production. Further analysis with both compounds indicated that they mainly affected the attachment and entry steps of the virus life cycle. Moreover, D and EGCG showed a direct effect on WNV particles exerting a virucidal effect. We showed a similar inhibition of viral production of these compounds on WNV variants that differed on acidic pH requirements for viral fusion, indicating that their antiviral activity against WNV is produced by a virucidal effect rather than by an inhibition of pH-dependent viral fusion. Both polyphenols also reduced the infectivity of ZIKV and DENV. Therefore, D and EGCG impair the infectivity in cell culture of these three medically relevant flaviviruses. |
X Demographics
The data shown below were collected from the profiles of 18 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Indonesia | 5 | 28% |
| Argentina | 1 | 6% |
| Iraq | 1 | 6% |
| Malaysia | 1 | 6% |
| Italy | 1 | 6% |
| Unknown | 9 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 17 | 94% |
| Scientists | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 178 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 178 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 31 | 17% |
| Student > Bachelor | 30 | 17% |
| Student > Ph. D. Student | 19 | 11% |
| Researcher | 14 | 8% |
| Student > Doctoral Student | 11 | 6% |
| Other | 25 | 14% |
| Unknown | 48 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 27 | 15% |
| Agricultural and Biological Sciences | 23 | 13% |
| Chemistry | 19 | 11% |
| Immunology and Microbiology | 12 | 7% |
| Medicine and Dentistry | 10 | 6% |
| Other | 30 | 17% |
| Unknown | 57 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 March 2023.
All research outputs
#2,027,926
of 24,557,820 outputs
Outputs from Frontiers in Microbiology
#1,449
of 27,892 outputs
Outputs of similar age
#38,426
of 316,786 outputs
Outputs of similar age from Frontiers in Microbiology
#57
of 542 outputs
Altmetric has tracked 24,557,820 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 27,892 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 316,786 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 542 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.