Title |
Focused Review: Cytotoxic and Antioxidant Potentials of Mangrove-Derived Streptomyces
|
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Published in |
Frontiers in Microbiology, November 2017
|
DOI | 10.3389/fmicb.2017.02065 |
Pubmed ID | |
Authors |
Hooi-Leng Ser, Loh Teng-Hern Tan, Jodi Woan-Fei Law, Kok-Gan Chan, Acharaporn Duangjai, Surasak Saokaew, Priyia Pusparajah, Nurul-Syakima Ab Mutalib, Tahir Mehmood Khan, Bey-Hing Goh, Learn-Han Lee |
Abstract |
Human life expectancy is rapidly increasing with an associated increasing burden of chronic diseases, such as neurodegenerative diseases and cancer. However, there is limited progress in finding effective treatment for these conditions. For this reason, members of the genus Streptomyces have been explored extensively over the past decades as these filamentous bacteria are highly efficient in producing bioactive compounds with human health benefits. Being ubiquitous in nature, streptomycetes can be found in both terrestrial and marine environments. Previously, two Streptomyces strains (MUSC 137(T) and MUM 256) isolated from mangrove sediments in Peninsular Malaysia demonstrated potent antioxidant and cytotoxic activities against several human cancer cell lines on bioactivity screening. These results illustrate the importance of streptomycetes from underexplored regions aside from the terrestrial ecosystem. Here we provide the insights and significance of Streptomyces species in the search of anticancer and/or chemopreventive agents and highlight the impact of next generation sequencing on drug discovery from the Streptomyces arsenal. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 20% |
Unknown | 4 | 80% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 84 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 16 | 19% |
Student > Master | 10 | 12% |
Researcher | 8 | 10% |
Student > Bachelor | 7 | 8% |
Student > Doctoral Student | 6 | 7% |
Other | 13 | 15% |
Unknown | 24 | 29% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 16 | 19% |
Biochemistry, Genetics and Molecular Biology | 14 | 17% |
Immunology and Microbiology | 6 | 7% |
Environmental Science | 5 | 6% |
Arts and Humanities | 2 | 2% |
Other | 9 | 11% |
Unknown | 32 | 38% |