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Rhinovirus Biology, Antigenic Diversity, and Advancements in the Design of a Human Rhinovirus Vaccine

Overview of attention for article published in Frontiers in Microbiology, December 2017
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1 X user
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1 research highlight platform

Citations

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53 Dimensions

Readers on

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137 Mendeley
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Title
Rhinovirus Biology, Antigenic Diversity, and Advancements in the Design of a Human Rhinovirus Vaccine
Published in
Frontiers in Microbiology, December 2017
DOI 10.3389/fmicb.2017.02412
Pubmed ID
Authors

Christopher C. Stobart, Jenna M. Nosek, Martin L. Moore

Abstract

Human rhinovirus (HRV) remains a leading cause of several human diseases including the common cold. Despite considerable research over the last 60 years, development of an effective vaccine to HRV has been viewed by many as unfeasible due, in part, to the antigenic diversity of circulating HRVs in nature. Over 150 antigenically distinct types of HRV are currently known which span three species: HRV A, HRV B, and HRV C. Early attempts to develop a rhinovirus vaccine have shown that inactivated HRV is capable of serving as a strong immunogen and inducing neutralizing antibodies. Yet, limitations to virus preparation and recovery, continued identification of antigenic variants of HRV, and logistical challenges pertaining to preparing a polyvalent preparation of the magnitude required for true efficacy against circulating rhinoviruses continue to prove a daunting challenge. In this review, we describe HRV biology, antigenic diversity, and past and present advances in HRV vaccine design.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 137 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 137 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 24 18%
Student > Master 20 15%
Researcher 16 12%
Student > Ph. D. Student 9 7%
Student > Doctoral Student 8 6%
Other 15 11%
Unknown 45 33%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 32 23%
Immunology and Microbiology 18 13%
Agricultural and Biological Sciences 12 9%
Medicine and Dentistry 10 7%
Chemistry 5 4%
Other 15 11%
Unknown 45 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 December 2021.
All research outputs
#15,619,274
of 24,744,050 outputs
Outputs from Frontiers in Microbiology
#14,164
of 28,173 outputs
Outputs of similar age
#249,015
of 450,328 outputs
Outputs of similar age from Frontiers in Microbiology
#330
of 521 outputs
Altmetric has tracked 24,744,050 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 28,173 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 450,328 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 521 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.