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Attention Score in Context
| Title |
Bovine Lactoferrin and Lactoferrin-Derived Peptides Inhibit the Growth of Vibrio cholerae and Other Vibrio species
|
|---|---|
| Published in |
Frontiers in Microbiology, January 2018
|
| DOI | 10.3389/fmicb.2017.02633 |
| Pubmed ID | |
| Authors |
Erika Acosta-Smith, Karina Viveros-Jiménez, Adrian Canizalez-Román, Magda Reyes-Lopez, Jan G. M. Bolscher, Kamran Nazmi, Hector Flores-Villaseñor, Gerardo Alapizco-Castro, Mireya de la Garza, Jesús J. Martínez-Garcia, Jorge Velazquez-Roman, Nidia Leon-Sicairos |
| Abstract |
Vibrio is a genus of Gram-negative bacteria, some of which can cause serious infectious diseases. Vibrio infections are associated with the consumption of contaminated food and classified in Vibrio cholera infections and non-cholera Vibrio infections. In the present study, we investigate whether bovine lactoferrin (bLF) and several synthetic peptides corresponding to bLF sequences, are able to inhibit the growth or have bactericidal effect against V. cholerae and other Vibrio species. The antibacterial activity of LF and LF-peptides was assessed by kinetics of growth or determination of colony forming unit in bacteria treated with the peptides and antibiotics. To get insight in the mode of action, the interaction between bLF and bLF-peptides (coupled to FITC) and V. cholera was evaluated. The damage of effector-induced bacterial membrane permeability was measured by inclusion of the fluorescent dye propidium iodide using flow cytometry, whereas the bacterial ultrastructural damage in bacteria treated was observed by transmission electron microscopy. The results showed that bLF and LFchimera inhibited the growth of the V. cholerae strains; LFchimera permeabilized the bacteria which membranes were seriously damaged. Assays with a multidrug-resistant strain of Vibrio species indicated that combination of sub-lethal doses of LFchimera with ampicillin or tetracycline strongly reduced the concentration of the antibiotics to reach 95% growth inhibition. Furthermore, LFchimera were effective to inhibit the V. cholerae counts and damage due to this bacterium in a model mice. These data suggest that LFchimera and bLF are potential candidates to combat the V. cholerae and other multidrug resistant Vibrio species. |
Mendeley readers
The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 58 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 19% |
| Student > Master | 8 | 14% |
| Student > Ph. D. Student | 6 | 10% |
| Professor | 4 | 7% |
| Student > Bachelor | 3 | 5% |
| Other | 6 | 10% |
| Unknown | 20 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 17% |
| Agricultural and Biological Sciences | 8 | 14% |
| Immunology and Microbiology | 5 | 9% |
| Medicine and Dentistry | 3 | 5% |
| Chemistry | 3 | 5% |
| Other | 6 | 10% |
| Unknown | 23 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 January 2018.
All research outputs
#5,807,468
of 23,016,919 outputs
Outputs from Frontiers in Microbiology
#5,520
of 25,134 outputs
Outputs of similar age
#115,997
of 443,312 outputs
Outputs of similar age from Frontiers in Microbiology
#184
of 544 outputs
Altmetric has tracked 23,016,919 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 25,134 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 443,312 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 544 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.