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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Preliminary Comparison of Oral and Intestinal Human Microbiota in Patients with Colorectal Cancer: A Pilot Study
|
|---|---|
| Published in |
Frontiers in Microbiology, January 2018
|
| DOI | 10.3389/fmicb.2017.02699 |
| Pubmed ID | |
| Authors |
Edda Russo, Giovanni Bacci, Carolina Chiellini, Camilla Fagorzi, Elena Niccolai, Antonio Taddei, Federica Ricci, Maria N. Ringressi, Rossella Borrelli, Filippo Melli, Manouela Miloeva, Paolo Bechi, Alessio Mengoni, Renato Fani, Amedeo Amedei |
| Abstract |
In this study Next-Generation Sequencing (NGS) was used to analyze and compare human microbiota from three different compartments, i.e., saliva, feces, and cancer tissue (CT), of a selected cohort of 10 Italian patients with colorectal cancer (CRC) vs. 10 healthy controls (saliva and feces). Furthermore, the Fusobacterium nucleatum abundance in the same body site was investigated through real-time quantitative polymerase chain reaction (qPCR) to assess the association with CRC. Differences in bacterial composition, F. nucleatum abundance in healthy controls vs. CRC patients, and the association of F. nucleatum with clinical parameters were observed. Taxonomic analysis based on 16S rRNA gene, revealed the presence of three main bacterial phyla, which includes about 80% of reads: Firmicutes (39.18%), Bacteroidetes (30.36%), and Proteobacteria (10.65%). The results highlighted the presence of different bacterial compositions; in particular, the fecal samples of CRC patients seemed to be enriched with Bacteroidetes, whereas in the fecal samples of healthy controls Firmicutes were one of the major phyla detected though these differences were not statistically significant. The CT samples showed the highest alpha diversity values. These results emphasize a different taxonomic composition of feces from CRC compared to healthy controls. Despite the low number of samples included in the study, these results suggest the importance of microbiota in the CRC progression and could pave the way to the development of therapeutic interventions and novel microbial-related diagnostic tools in CRC patients. |
X Demographics
The data shown below were collected from the profiles of 40 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 4 | 10% |
| India | 3 | 8% |
| United States | 2 | 5% |
| Canada | 2 | 5% |
| Switzerland | 2 | 5% |
| Spain | 2 | 5% |
| Thailand | 1 | 3% |
| Colombia | 1 | 3% |
| Costa Rica | 1 | 3% |
| Other | 4 | 10% |
| Unknown | 18 | 45% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 32 | 80% |
| Scientists | 8 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 129 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 129 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 26 | 20% |
| Student > Bachelor | 19 | 15% |
| Student > Ph. D. Student | 16 | 12% |
| Student > Master | 13 | 10% |
| Student > Postgraduate | 7 | 5% |
| Other | 19 | 15% |
| Unknown | 29 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 31 | 24% |
| Medicine and Dentistry | 26 | 20% |
| Agricultural and Biological Sciences | 17 | 13% |
| Immunology and Microbiology | 11 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Other | 9 | 7% |
| Unknown | 33 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 33. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2020.
All research outputs
#1,174,346
of 24,995,611 outputs
Outputs from Frontiers in Microbiology
#665
of 28,624 outputs
Outputs of similar age
#27,484
of 454,999 outputs
Outputs of similar age from Frontiers in Microbiology
#15
of 545 outputs
Altmetric has tracked 24,995,611 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 28,624 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 454,999 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 545 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.