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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A Novel Antimicrobial Coating Represses Biofilm and Virulence-Related Genes in Methicillin-Resistant Staphylococcus aureus
|
|---|---|
| Published in |
Frontiers in Microbiology, February 2018
|
| DOI | 10.3389/fmicb.2018.00221 |
| Pubmed ID | |
| Authors |
Ankita Vaishampayan, Anne de Jong, Darren J. Wight, Jan Kok, Elisabeth Grohmann |
| Abstract |
Methicillin-resistantStaphylococcus aureus(MRSA) has become an important cause of hospital-acquired infections worldwide. It is one of the most threatening pathogens due to its multi-drug resistance and strong biofilm-forming capacity. Thus, there is an urgent need for novel alternative strategies to combat bacterial infections. Recently, we demonstrated that a novel antimicrobial surface coating, AGXX®, consisting of micro-galvanic elements of the two noble metals, silver and ruthenium, surface-conditioned with ascorbic acid, efficiently inhibits MRSA growth. In this study, we demonstrated that the antimicrobial coating caused a significant reduction in biofilm formation (46%) of the clinical MRSA isolate,S. aureus04-02981. To understand the molecular mechanism of the antimicrobial coating, we exposedS. aureus04-02981 for different time-periods to the coating and investigated its molecular response via next-generation RNA-sequencing. A conventional antimicrobial silver coating served as a control. RNA-sequencing demonstrated down-regulation of many biofilm-associated genes and of genes related to virulence ofS. aureus. The antimicrobial substance also down-regulated the two-component quorum-sensing systemagrsuggesting that it might interfere with quorum-sensing while diminishing biofilm formation inS. aureus04-02981. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 69 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 16 | 23% |
| Student > Ph. D. Student | 12 | 17% |
| Researcher | 9 | 13% |
| Student > Bachelor | 7 | 10% |
| Professor | 3 | 4% |
| Other | 6 | 9% |
| Unknown | 16 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 12 | 17% |
| Agricultural and Biological Sciences | 10 | 14% |
| Immunology and Microbiology | 7 | 10% |
| Chemistry | 5 | 7% |
| Medicine and Dentistry | 5 | 7% |
| Other | 13 | 19% |
| Unknown | 17 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 August 2020.
All research outputs
#3,149,684
of 23,025,074 outputs
Outputs from Frontiers in Microbiology
#2,915
of 25,149 outputs
Outputs of similar age
#82,134
of 474,295 outputs
Outputs of similar age from Frontiers in Microbiology
#93
of 558 outputs
Altmetric has tracked 23,025,074 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 25,149 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 474,295 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 558 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.