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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Staphylococcus aureus Membrane-Derived Vesicles Promote Bacterial Virulence and Confer Protective Immunity in Murine Infection Models
|
|---|---|
| Published in |
Frontiers in Microbiology, February 2018
|
| DOI | 10.3389/fmicb.2018.00262 |
| Pubmed ID | |
| Authors |
Fatemeh Askarian, John D. Lapek, Mitesh Dongre, Chih-Ming Tsai, Monika Kumaraswamy, Armin Kousha, J. Andrés Valderrama, Judith A. Ludviksen, Jorunn P. Cavanagh, Satoshi Uchiyama, Tom E. Mollnes, David J. Gonzalez, Sun N. Wai, Victor Nizet, Mona Johannessen |
| Abstract |
Staphylococcus aureus produces membrane-derived vesicles (MVs), which share functional properties to outer membrane vesicles. Atomic force microscopy revealed that S. aureus-derived MVs are associated with the bacterial surface or released into the surrounding environment depending on bacterial growth conditions. By using a comparative proteomic approach, a total of 131 and 617 proteins were identified in MVs isolated from S. aureus grown in Luria-Bertani and brain-heart infusion broth, respectively. Purified S. aureus MVs derived from the bacteria grown in either media induced comparable levels of cytotoxicity and neutrophil-activation. Administration of exogenous MVs increased the resistance of S. aureus to killing by whole blood or purified human neutrophils ex vivo and increased S. aureus survival in vivo. Finally, immunization of mice with S. aureus-derived MVs induced production of IgM, total IgG, IgG1, IgG2a, and IgG2b resulting in protection against subcutaneous and systemic S. aureus infection. Collectively, our results suggest S. aureus MVs can influence bacterial-host interactions during systemic infections and provide protective immunity in murine models of infection. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Germany | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 83 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 19% |
| Student > Bachelor | 13 | 16% |
| Researcher | 12 | 14% |
| Student > Doctoral Student | 10 | 12% |
| Student > Master | 6 | 7% |
| Other | 10 | 12% |
| Unknown | 16 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 16 | 19% |
| Immunology and Microbiology | 13 | 16% |
| Agricultural and Biological Sciences | 12 | 14% |
| Medicine and Dentistry | 5 | 6% |
| Engineering | 4 | 5% |
| Other | 8 | 10% |
| Unknown | 25 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2018.
All research outputs
#17,930,799
of 23,023,224 outputs
Outputs from Frontiers in Microbiology
#17,430
of 25,149 outputs
Outputs of similar age
#240,510
of 331,055 outputs
Outputs of similar age from Frontiers in Microbiology
#447
of 588 outputs
Altmetric has tracked 23,023,224 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 25,149 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,055 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 588 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.