The primary virulence factor of the skin commensal and opportunistic pathogen,Staphylococcus epidermidis, is the ability to form biofilms on surfaces of implanted materials. Much of this microorganism's pathogenic success has been attributed to its ability to evade the innate immune system. The primary defense againstS. epidermidisbiofilm infection consists of complement activation, recruitment and subsequent killing of the pathogen by effector cells. Among pathogen-derived factors, the biofilm exopolysaccharide polysaccharide intercellular adhesion (PIA), as well as the accumulation-associated protein (Aap), and the extracellular matrix binding protein (Embp) have been shown to modulate effector cell-mediated killing ofS. epidermidis. Phenol-soluble modulins (PSMs) constitute the only class of secreted toxins byS. epidermidis, at least one type of which (PSMδ) possesses strong cytolytic properties toward leukocytes. However, through selective production of non-cytolytic subtypes of PSMs,S. epidermidisis able to maintain a low inflammatory infection profile and avoid eradication by the host immune system. Taken together, our emerging understanding of the mechanisms behind immune modulation byS. epidermidiselucidates the microorganism's success in the initial colonization of device surfaces as well as the maintenance of a chronic and indolent course of biofilm infection.