Title |
Pangenomic Definition of Prokaryotic Species and the Phylogenetic Structure of Prochlorococcus spp.
|
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Published in |
Frontiers in Microbiology, March 2018
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DOI | 10.3389/fmicb.2018.00428 |
Pubmed ID | |
Authors |
Mikhail A. Moldovan, Mikhail S. Gelfand |
Abstract |
The pangenome is the collection of all groups of orthologous genes (OGGs) from a set of genomes. We apply the pangenome analysis to propose a definition of prokaryotic species based on identification of lineage-specific gene sets. While being similar to the classical biological definition based on allele flow, it does not rely on DNA similarity levels and does not require analysis of homologous recombination. Hence this definition is relatively objective and independent of arbitrary thresholds. A systematic analysis of 110 accepted species with the largest numbers of sequenced strains yields results largely consistent with the existing nomenclature. However, it has revealed that abundant marine cyanobacteriaProchlorococcus marinusshould be divided into two species. As a control we have confirmed the paraphyletic origin ofYersinia pseudotuberculosis(with embedded, monophyleticY. pestis) andBurkholderia pseudomallei(withB. mallei). We also demonstrate that by our definition and in accordance with recent studiesEscherichia coliandShigellaspp. are one species. |
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Members of the public | 18 | 40% |
Mendeley readers
Geographical breakdown
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Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 14 | 15% |
Researcher | 12 | 13% |
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Professor | 6 | 7% |
Other | 9 | 10% |
Unknown | 19 | 21% |
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Environmental Science | 5 | 5% |
Other | 8 | 9% |
Unknown | 23 | 25% |