Forty-five KPC-producingEnterobacteriaceaestrains were isolated from multiple departments in a Chinese public hospital from 2014 to 2015. Genome sequencing of four representative strains, namelyProteus mirabilisGN2,Serratia marcescensGN26,Morganella morganiiGN28, andKlebsiella aerogenesE20, indicated the presence ofblaKPC-2-carrying IncX6 plasmids pGN2-KPC, pGN26-KPC, pGN28-KPC, and pE20-KPC in the four strains, respectively. These plasmids were genetically closely related to one another and to the only previously sequenced IncX6 plasmid, pKPC3_SZ. Each of the plasmids carried a single accessory module containing theblaKPC-2/3-carrying ΔTn6296derivatives. The ΔTn6292element from pGN26-KPC also containedqnrS, which was absent from all other plasmids. Overall, pKPC3_SZ-likeblaKPC-carrying IncX6 plasmids were detected by PCR in 44.4% of the KPC-producing isolates, which includedK. aerogenes, P. mirabilis, S. marcescens, M. morganii, Escherichia coli, andKlebsiella pneumoniae, and were obtained from six different departments of the hospital. Data presented herein provided insights into the genomic diversity and evolution of IncX6 plasmids, as well as the dissemination and epidemiology ofblaKPC-carrying IncX6 plasmids amongEnterobacteriaceaein a hospital setting.