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Mendeley readers
Attention Score in Context
| Title |
Altered Mycobacterium tuberculosis Cell Wall Metabolism and Physiology Associated With RpoB Mutation H526D
|
|---|---|
| Published in |
Frontiers in Microbiology, March 2018
|
| DOI | 10.3389/fmicb.2018.00494 |
| Pubmed ID | |
| Authors |
Victoria L. Campodónico, Dalin Rifat, Yu-Min Chuang, Thomas R. Ioerger, Petros C. Karakousis |
| Abstract |
Background: Mycobacterium tuberculosis (Mtb)rpoBmutations are associated with global metabolic remodeling. However, the net effects ofrpoBmutations on Mtb physiology, metabolism and function are not completely understood. Based on previous work, we hypothesized that changes in the expression of cell wall molecules in Mtb mutant RpoB 526D lead to changes in cell wall permeability and to altered resistance to environmental stresses and drugs.Methods:The phenotypes of a fully drug-susceptible clinical strain of Mtb and its paired rifampin-monoresistant, RpoB H526D mutant progeny strain were compared.Results:TherpoBmutant showed altered colony morphology, bacillary length and cell wall thickness, which were associated with increased cell wall permeability and susceptibility to the cell wall detergent sodium dodecyl sulfate (SDS) after exposure to nutrient starvation. Relative to the isogenic rifampin-susceptible strain, the RpoB H526D mutant showed altered bacterial cellular metabolic activity and an eightfold increase in susceptibility to the cell-wall acting drug vancomycin.Conclusion:Our data suggest that RpoB mutation H526D is associated with altered cell wall physiology and resistance to cell wall-related stress. These findings are expected to contribute to an improved understanding of the pathogenesis of drug-resistantM. tuberculosisinfections. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 68 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 14 | 21% |
| Researcher | 10 | 15% |
| Student > Bachelor | 8 | 12% |
| Student > Ph. D. Student | 7 | 10% |
| Professor | 3 | 4% |
| Other | 9 | 13% |
| Unknown | 17 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 17 | 25% |
| Immunology and Microbiology | 12 | 18% |
| Agricultural and Biological Sciences | 8 | 12% |
| Medicine and Dentistry | 5 | 7% |
| Computer Science | 2 | 3% |
| Other | 3 | 4% |
| Unknown | 21 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 May 2020.
All research outputs
#13,229,066
of 23,313,051 outputs
Outputs from Frontiers in Microbiology
#9,499
of 25,626 outputs
Outputs of similar age
#162,354
of 333,079 outputs
Outputs of similar age from Frontiers in Microbiology
#296
of 604 outputs
Altmetric has tracked 23,313,051 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 25,626 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 333,079 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 604 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.