Title |
Lipid Bodies as Sites of Prostaglandin E2 Synthesis During Chagas Disease: Impact in the Parasite Escape Mechanism
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Published in |
Frontiers in Microbiology, March 2018
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DOI | 10.3389/fmicb.2018.00499 |
Pubmed ID | |
Authors |
Patrícia E. de Almeida, Daniel A. M. Toledo, Gabriel S. C. Rodrigues, Heloisa D’Avila |
Abstract |
During Chagas disease, theTrypanosoma cruzican induce some changes in the host cells in order to escape or manipulate the host immune response. The modulation of the lipid metabolism in the host phagocytes or in the parasite itself is one feature that has been observed. The goal of this mini review is to discuss the mechanisms that regulate intracellular lipid body (LB) biogenesis in the course of this parasite infection and their meaning to the pathophysiology of the disease. The interaction host-parasite induces LB (or lipid droplet) formation in a Toll-like receptor 2-dependent mechanism in macrophages and is enhanced by apoptotic cell uptake. Simultaneously, there is a lipid accumulation in the parasite due to the incorporation of host fatty acids. The increase in the LB accumulation during infection is correlated with an increase in the synthesis of PGE2within the host cells and the parasite LBs. Moreover, the treatment with fatty acid synthase inhibitor C75 or non-steroidal anti-inflammatory drugs such as NS-398 and aspirin inhibited the LB biogenesis and also induced the down modulation of the eicosanoid production and the parasite replication. These findings show that LBs are organelles up modulated during the course of infection. Furthermore, the biogenesis of the LB is involved in the lipid mediator generation by both the macrophages and the parasite triggering escape mechanisms. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 57 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 8 | 14% |
Student > Doctoral Student | 7 | 12% |
Researcher | 6 | 11% |
Student > Master | 6 | 11% |
Student > Ph. D. Student | 4 | 7% |
Other | 7 | 12% |
Unknown | 19 | 33% |
Readers by discipline | Count | As % |
---|---|---|
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Agricultural and Biological Sciences | 10 | 18% |
Biochemistry, Genetics and Molecular Biology | 7 | 12% |
Chemistry | 3 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 2 | 4% |
Unknown | 22 | 39% |