Title |
Galactomannan, a Surrogate Marker for Outcome in Invasive Aspergillosis: Finally Coming of Age
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Published in |
Frontiers in Microbiology, April 2018
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DOI | 10.3389/fmicb.2018.00661 |
Pubmed ID | |
Authors |
Toine Mercier, Ellen Guldentops, Katrien Lagrou, Johan Maertens |
Abstract |
Detection of galactomannan has become widely available for diagnosing invasive aspergillosis. The test characteristics, using the Platelia™ enzyme-immunoassay, have been well described. This assay could potentially also be useful for the early evaluation of the efficacy of antifungal therapy and for predicting the outcome in terms of response and survival. In this systematic review, we assessed the available evidence for the use of serum galactomannan at baseline as a prognostic marker, and the predictive value of serum galactomannan kinetics after initiation of antifungal therapy. Overall, serum galactomannan at baseline and galactomannan kinetics appear to be good predictors of therapy response and survival. However, breakpoints for predicting therapy failure and validation in different patient populations are still lacking. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 33% |
United Kingdom | 1 | 11% |
Unknown | 5 | 56% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 56% |
Scientists | 3 | 33% |
Practitioners (doctors, other healthcare professionals) | 1 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 64 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 11 | 17% |
Student > Ph. D. Student | 8 | 13% |
Student > Bachelor | 7 | 11% |
Student > Postgraduate | 4 | 6% |
Student > Master | 4 | 6% |
Other | 8 | 13% |
Unknown | 22 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 20 | 31% |
Biochemistry, Genetics and Molecular Biology | 5 | 8% |
Immunology and Microbiology | 5 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
Agricultural and Biological Sciences | 3 | 5% |
Other | 3 | 5% |
Unknown | 25 | 39% |