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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Pivotal Role of DNA Repair in Infection Mediated-Inflammation and Cancer
|
|---|---|
| Published in |
Frontiers in Microbiology, April 2018
|
| DOI | 10.3389/fmicb.2018.00663 |
| Pubmed ID | |
| Authors |
Ayse Z. Sahan, Tapas K. Hazra, Soumita Das |
| Abstract |
Pathogenic and commensal microbes induce various levels of inflammation and metabolic disease in the host. Inflammation caused by infection leads to increased production of reactive oxygen species (ROS) and subsequent oxidative DNA damage. These in turn cause further inflammation and exacerbation of DNA damage, and pose a risk for cancer development. Helicobacter pylori-mediated inflammation has been implicated in gastric cancer in many previously established studies, and Fusobacterium nucleatum presence has been observed with greater intensity in colorectal cancer patients. Despite ambiguity in the exact mechanism, infection-mediated inflammation may have a link to cancer development through an accumulation of potentially mutagenic DNA damage in surrounding cells. The multiple DNA repair pathways such as base excision, nucleotide excision, and mismatch repair that are employed by cells are vital in the abatement of accumulated mutations that can lead to carcinogenesis. For this reason, understanding the role of DNA repair as an important cellular mechanism in combatting the development of cancer will be essential to characterizing the effect of infection on DNA repair proteins and to identifying early cancer biomarkers that may be targeted for cancer therapies and treatments. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 87 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 15 | 17% |
| Student > Ph. D. Student | 11 | 13% |
| Student > Doctoral Student | 10 | 11% |
| Student > Master | 10 | 11% |
| Other | 6 | 7% |
| Other | 11 | 13% |
| Unknown | 24 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 27 | 31% |
| Immunology and Microbiology | 9 | 10% |
| Medicine and Dentistry | 8 | 9% |
| Agricultural and Biological Sciences | 7 | 8% |
| Chemistry | 4 | 5% |
| Other | 8 | 9% |
| Unknown | 24 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 April 2018.
All research outputs
#18,909,315
of 24,093,053 outputs
Outputs from Frontiers in Microbiology
#18,917
of 27,122 outputs
Outputs of similar age
#243,775
of 332,875 outputs
Outputs of similar age from Frontiers in Microbiology
#429
of 586 outputs
Altmetric has tracked 24,093,053 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 27,122 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 332,875 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 586 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.