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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Fecal Microbiota Transplantation Ameliorates Experimentally Induced Colitis in Mice by Upregulating AhR
|
|---|---|
| Published in |
Frontiers in Microbiology, August 2018
|
| DOI | 10.3389/fmicb.2018.01921 |
| Pubmed ID | |
| Authors |
Yan-Ling Wei, Yu-Qin Chen, Hao Gong, Ning Li, Kang-Qi Wu, Wang Hu, Bin Wang, Kai-Jun Liu, Liang-Zhi Wen, Xiao Xiao, Dong-Feng Chen |
| Abstract |
Ulcerative colitis (UC) is a chronic non-specific inflammatory disease that occurs in the colon and rectum. While fecal microbiota transplantation (FMT) is gaining attention as a clinical treatment of UC, the molecular mechanisms behind this effect have yet to be fully understood. A C57BL/6 mouse model was established to test whether FMT promotes the recovery of colon inflammation. Administration of 2% dextran sulfate sodium (DSS) for 7 days successfully induced acute colitis, as evidenced by diarrhea, hematochezia and colon shortening as well as a decrease in body weight. FMT alleviated the severity of colon mucosa injury and improved histological alterations compared with that of the DSS group. In addition, FMT promoted homeostasis of the intestinal microbiota. Furthermore, FMT upregulated the expression of aryl hydrocarbon receptor (AHR), interleukin-10 (IL-10), and transforming growth factor beta (TGF-β) in colon tissues. These results suggest that the significant anti-inflammatory effect of FMT may be attributed to its promotion of IL-10 and TGF-β production and AHR activation. Based on these results, FMT had a favorable therapeutic effect on DSS-induced colitis. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 17% |
| Switzerland | 1 | 17% |
| Unknown | 4 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 67% |
| Scientists | 2 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 63 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 12 | 19% |
| Student > Ph. D. Student | 10 | 16% |
| Student > Bachelor | 6 | 10% |
| Student > Doctoral Student | 5 | 8% |
| Student > Postgraduate | 4 | 6% |
| Other | 8 | 13% |
| Unknown | 18 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 16% |
| Immunology and Microbiology | 9 | 14% |
| Medicine and Dentistry | 8 | 13% |
| Agricultural and Biological Sciences | 8 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
| Other | 7 | 11% |
| Unknown | 19 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 September 2018.
All research outputs
#3,311,934
of 23,100,534 outputs
Outputs from Frontiers in Microbiology
#3,136
of 25,279 outputs
Outputs of similar age
#68,616
of 334,198 outputs
Outputs of similar age from Frontiers in Microbiology
#137
of 720 outputs
Altmetric has tracked 23,100,534 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 25,279 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 334,198 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 720 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.