Title |
Novel Bacteriophages Capable of Disrupting Biofilms From Clinical Strains of Aeromonas hydrophila
|
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Published in |
Frontiers in Microbiology, February 2020
|
DOI | 10.3389/fmicb.2020.00194 |
Pubmed ID | |
Authors |
Mwila Kabwe, Teagan Brown, Lachlan Speirs, Heng Ku, Michael Leach, Hiu Tat Chan, Steve Petrovski, Peter Lock, Joseph Tucci |
Abstract |
The increase in global warming has favored growth of a range of opportunistic environmental bacteria and allowed some of these to become more pathogenic to humans. Aeromonas hydrophila is one such organism. Surviving in moist conditions in temperate climates, these bacteria have been associated with a range of diseases in humans, and in systemic infections can cause mortality in up to 46% of cases. Their capacity to form biofilms, carry antibiotic resistance mechanisms, and survive disinfection, has meant that they are not easily treated with traditional methods. Bacteriophage offer a possible alternative approach for controlling their growth. This study is the first to report the isolation and characterization of bacteriophages lytic against clinical strains of A. hydrophila which carry intrinsic antibiotic resistance genes. Functionally, these novel bacteriophages were shown to be capable of disrupting biofilms caused by clinical isolates of A. hydrophila. The potential exists for these to be tested in clinical and environmental settings. |
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Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 14% |
India | 1 | 7% |
Spain | 1 | 7% |
Venezuela, Bolivarian Republic of | 1 | 7% |
Mexico | 1 | 7% |
Switzerland | 1 | 7% |
Unknown | 7 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 11 | 79% |
Scientists | 3 | 21% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 36 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 14% |
Student > Bachelor | 4 | 11% |
Student > Master | 4 | 11% |
Student > Doctoral Student | 3 | 8% |
Researcher | 3 | 8% |
Other | 4 | 11% |
Unknown | 13 | 36% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 5 | 14% |
Immunology and Microbiology | 5 | 14% |
Veterinary Science and Veterinary Medicine | 4 | 11% |
Environmental Science | 2 | 6% |
Medicine and Dentistry | 2 | 6% |
Other | 3 | 8% |
Unknown | 15 | 42% |