Title |
Futuristic Non-antibiotic Therapies to Combat Antibiotic Resistance: A Review
|
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Published in |
Frontiers in Microbiology, January 2021
|
DOI | 10.3389/fmicb.2021.609459 |
Pubmed ID | |
Authors |
Manoj Kumar, Devojit Kumar Sarma, Swasti Shubham, Manoj Kumawat, Vinod Verma, Praveen Balabaskaran Nina, Devraj Jp, Santosh Kumar, Birbal Singh, Rajnarayan R Tiwari |
Abstract |
The looming problem of resistance to antibiotics in microorganisms is a global health concern. The drug-resistant microorganisms originating from anthropogenic sources and commercial livestock farming have posed serious environmental and health challenges. Antibiotic-resistant genes constituting the environmental "resistome" get transferred to human and veterinary pathogens. Hence, deciphering the origin, mechanism and extreme of transfer of these genetic factors into pathogens is extremely important to develop not only the therapeutic interventions to curtail the infections, but also the strategies to avert the menace of microbial drug-resistance. Clinicians, researchers and policymakers should jointly come up to develop the strategies to prevent superfluous exposure of pathogens to antibiotics in non-clinical settings. This article highlights the present scenario of increasing antimicrobial-resistance in pathogenic bacteria and the clinical importance of unconventional or non-antibiotic therapies to thwart the infectious pathogenic microorganisms. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Venezuela, Bolivarian Republic of | 1 | 25% |
Ecuador | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 3 | 75% |
Members of the public | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 281 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 34 | 12% |
Student > Ph. D. Student | 30 | 11% |
Researcher | 22 | 8% |
Student > Master | 22 | 8% |
Student > Doctoral Student | 12 | 4% |
Other | 37 | 13% |
Unknown | 124 | 44% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 41 | 15% |
Immunology and Microbiology | 25 | 9% |
Agricultural and Biological Sciences | 21 | 7% |
Medicine and Dentistry | 16 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 12 | 4% |
Other | 39 | 14% |
Unknown | 127 | 45% |