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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Continual Decline in Azole Susceptibility Rates in Candida tropicalis Over a 9-Year Period in China
|
|---|---|
| Published in |
Frontiers in Microbiology, July 2021
|
| DOI | 10.3389/fmicb.2021.702839 |
| Pubmed ID | |
| Authors |
Yao Wang, Xin Fan, He Wang, Timothy Kudinha, Ya-Ning Mei, Fang Ni, Yu-Hong Pan, Lan-Mei Gao, Hui Xu, Hai-Shen Kong, Qing Yang, Wei-Ping Wang, Hai-Yan Xi, Yan-Ping Luo, Li-Yan Ye, Meng Xiao, China Hospital Invasive Fungal Surveillance Net Study Group, Zi-Yong Sun, Zhong-Jv Chen, Ying-Chun Xu, Meng Xiao, Mei Kang, Yu-Ling Xiao, Ya-Ning Mei, Fang Ni, Yu-Hong Pan, Lan-Mei Gao, Hui Xu, Hui Xu, Kang Liao, Peng-Hao Guo, Hai-Shen Kong, Qing Yang, Wei-Ping Wang, Yan-Ping Luo, Li-Yan Ye, Hua Yu, Lin Yin, Da-Wen Guo, Lan-Ying Cui, Peng-Peng Liu, Hong He, Yan Jin, Hui Fan, Yun-Song Yu, Jie Lin, Ruo-Yu Li, Zhe Wan, Ling Ma, Shuai-Xian Du, Wen-En Liu, Yan-Ming Li, Tie-Li Zhou, Qing Wu, Xin-Lan Hu, Ning Li, Rong Zhang, Hong-Wei Zhou, Yi-Min Li, Dan-Hong Su, Qiang-Qiang Zhang, Li Li, Yun Xia, Li Yan, Zhi-Dong Hu, Na Yue, Yan Jiang, Zhi-Yong Liu, Yu-Ting Zheng, Wei Cao, Yun-Zhuo Chu, Fu-Shun Li, Yun Liu, Yuan-Hong Xu, Ying Huang, Wei Jia, Gang Li, Huo-Xiang Lv, Qing-Feng Hu, Xiu-Li Xu, Xiao-Yan Chen, Xiao-Ling Ma, Huai-Wei Lu, Yin-Mei Yang, Hui-Ling Chen, Jian-Sheng Huang, Hui Jing, Bin San, Yan Du, Hong-Jie Liang, Bin Yang, Yu-Lan Lin, Shan-Mei Wang, Qiong Ma, Hong-Mei Zhao, Li-Wen Liu, Qing Zhang, Fei Xia, Jin-Ying Wu, Mao-Li Yi, Xiang-Yang Chen, Wei-Ping Lu, Xiao-Yan Zeng, Jing Zhang, Jing Wang, Xiao-Guang Xiao, Jia-Yin Liang, Fan-Hua Huang, Gui-Ling Zou, Xue-Fei Du, Xiao-Ming Wang, Xu-Feng Ji, Yong Liu, Zhi-Jie Zhang, Yu-Xing Ni, Sheng-Yuan Zhao, Xiu-Lan Song, Chun-Yan Xu, Chun-Yan Xu, Lin Meng, Xian-Feng Zhang, Jian-Hong Zhao, Hong-Lian Wei, Xue-Song Xu, Weil Li, Yu-Ping Wang, Mei Xu, Yun-Duo Wang, Jing Song, Tian-Pen Cui, Zhi-Min Hu, Ting-Yin Zhou, Hai-Qing Hu, Xiao-Min Xu, Shan-Yan Liang, Lin-Qiang Deng, Hui Chen, Xiao-Jun Sun, Hai-Bin Wang, Jian-Bang Kang, Tie-Ying Hou, Ping Ji, Na Chen, Wen-Jun Sui, Hai-Tong Gu, Xiao-Qin Ha, Yuan-Yuan Zhang, Shu-Feng Wang, Hong Lu, Yi-Hai Gu, Xuan Hou, Rong Tang, Yan-Yan Guo, Fei Huang, Long-Hua Hu, Xiao-Yan Hu, Juan Li, Lian-Hua Wei, Dan Liu, Yan-Qiu Han, Yi-Hui Yao, Jian-Sheng Wang, Jie Wang, Wei Li, Li-Ping Ning, Wei-Qing Song, Yu-Jie Wang, Liang Luan |
| Abstract |
There have been reports of increasing azole resistance in Candida tropicalis, especially in the Asia-Pacific region. Here we report on the epidemiology and antifungal susceptibility of C. tropicalis causing invasive candidiasis in China, from a 9-year surveillance study. From August 2009 to July 2018, C. tropicalis isolates (n = 3702) were collected from 87 hospitals across China. Species identification was carried out by mass spectrometry or rDNA sequencing. Antifungal susceptibility was determined by Clinical and Laboratory Standards Institute disk diffusion (CHIF-NET10-14, n = 1510) or Sensititre YeastOne (CHIF-NET15-18, n = 2192) methods. Overall, 22.2% (823/3702) of the isolates were resistant to fluconazole, with 90.4% (744/823) being cross-resistant to voriconazole. In addition, 16.9 (370/2192) and 71.7% (1572/2192) of the isolates were of non-wild-type phenotype to itraconazole and posaconazole, respectively. Over the 9 years of surveillance, the fluconazole resistance rate continued to increase, rising from 5.7 (7/122) to 31.8% (236/741), while that for voriconazole was almost the same, rising from 5.7 (7/122) to 29.1% (216/741), with no significant statistical differences across the geographic regions. However, significant difference in fluconazole resistance rate was noted between isolates cultured from blood (27.2%, 489/1799) and those from non-blood (17.6%, 334/1903) specimens (P-value < 0.05), and amongst isolates collected from medical wards (28.1%, 312/1110) versus intensive care units (19.6%, 214/1092) and surgical wards (17.9%, 194/1086) (Bonferroni adjusted P-value < 0.05). Although echinocandin resistance remained low (0.8%, 18/2192) during the surveillance period, it was observed in most administrative regions, and one-third (6/18) of these isolates were simultaneously resistant to fluconazole. The continual decrease in the rate of azole susceptibility among C. tropicalis strains has become a nationwide challenge in China, and the emergence of multi-drug resistance could pose further threats. These phenomena call for effective efforts in future interventions. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Peru | 1 | 13% |
| India | 1 | 13% |
| Netherlands | 1 | 13% |
| France | 1 | 13% |
| Switzerland | 1 | 13% |
| Unknown | 3 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 50% |
| Scientists | 3 | 38% |
| Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 19 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 4 | 21% |
| Other | 2 | 11% |
| Student > Bachelor | 2 | 11% |
| Student > Doctoral Student | 1 | 5% |
| Student > Ph. D. Student | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 8 | 42% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 4 | 21% |
| Agricultural and Biological Sciences | 1 | 5% |
| Psychology | 1 | 5% |
| Social Sciences | 1 | 5% |
| Medicine and Dentistry | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 10 | 53% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 August 2021.
All research outputs
#8,215,959
of 25,443,857 outputs
Outputs from Frontiers in Microbiology
#8,673
of 29,374 outputs
Outputs of similar age
#164,123
of 450,022 outputs
Outputs of similar age from Frontiers in Microbiology
#289
of 1,153 outputs
Altmetric has tracked 25,443,857 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 29,374 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 450,022 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 1,153 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.