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LOV-based optogenetic devices: light-driven modules to impart photoregulated control of cellular signaling

Overview of attention for article published in Frontiers in Molecular Biosciences, May 2015
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  • Above-average Attention Score compared to outputs of the same age (55th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (54th percentile)

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6 X users

Citations

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183 Dimensions

Readers on

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468 Mendeley
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Title
LOV-based optogenetic devices: light-driven modules to impart photoregulated control of cellular signaling
Published in
Frontiers in Molecular Biosciences, May 2015
DOI 10.3389/fmolb.2015.00018
Pubmed ID
Authors

Ashutosh Pudasaini, Kaley K. El-Arab, Brian D. Zoltowski

Abstract

The Light-Oxygen-Voltage domain family of proteins is widespread in biology where they impart sensory responses to signal transduction domains. The small, light responsive LOV modules offer a novel platform for the construction of optogenetic tools. Currently, the design and implementation of these devices is partially hindered by a lack of understanding of how light drives allosteric changes in protein conformation to activate diverse signal transduction domains. Further, divergent photocycle properties amongst LOV family members complicate construction of highly sensitive devices with fast on/off kinetics. In the present review we discuss the history of LOV domain research with primary emphasis on tuning LOV domain chemistry and signal transduction to allow for improved optogenetic tools.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 468 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 <1%
Switzerland 1 <1%
Germany 1 <1%
Austria 1 <1%
France 1 <1%
Unknown 462 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 104 22%
Researcher 69 15%
Student > Bachelor 61 13%
Student > Master 58 12%
Student > Doctoral Student 26 6%
Other 56 12%
Unknown 94 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 154 33%
Agricultural and Biological Sciences 98 21%
Chemistry 44 9%
Neuroscience 23 5%
Engineering 18 4%
Other 36 8%
Unknown 95 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 May 2017.
All research outputs
#12,710,400
of 22,765,347 outputs
Outputs from Frontiers in Molecular Biosciences
#750
of 3,742 outputs
Outputs of similar age
#116,481
of 264,425 outputs
Outputs of similar age from Frontiers in Molecular Biosciences
#12
of 24 outputs
Altmetric has tracked 22,765,347 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,742 research outputs from this source. They receive a mean Attention Score of 3.3. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,425 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.