Title |
MicroRNAs as potential target in human bone and soft tissue sarcoma therapeutics
|
---|---|
Published in |
Frontiers in Molecular Biosciences, June 2015
|
DOI | 10.3389/fmolb.2015.00031 |
Pubmed ID | |
Authors |
Jyotika Varshney, Subbaya Subramanian |
Abstract |
Sarcomas are highly aggressive heterogeneous tumors that are mesenchymal in origin. There have been vast advancements on identifying diagnostic markers for sarcomas including chromosomal translocations, but very little progress has been made to identify targeted therapies against them. The tumor heterogeneity, genetic complexity and the lack of drug studies make it challenging to recognize the potential targets and also accounts for the inadequate treatments in sarcomas. In recent years, microRNAs that are a part of small non-coding RNAs have shown promising results as potential diagnostic and prognostic biomarkers in multiple sarcoma types. This review focuses on the current knowledge of the microRNAs that are deregulated in sarcomas, and an insight on the strategies to target these microRNAs that are essential for developing improved therapies for various human sarcomas. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 33% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 28 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 6 | 21% |
Student > Bachelor | 5 | 18% |
Student > Master | 4 | 14% |
Student > Ph. D. Student | 3 | 11% |
Professor | 2 | 7% |
Other | 4 | 14% |
Unknown | 4 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 8 | 29% |
Medicine and Dentistry | 6 | 21% |
Agricultural and Biological Sciences | 4 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Veterinary Science and Veterinary Medicine | 1 | 4% |
Other | 0 | 0% |
Unknown | 8 | 29% |