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Mendeley readers
Attention Score in Context
| Title |
Insights into the molecular mechanism of allostery in Hsp70s
|
|---|---|
| Published in |
Frontiers in Molecular Biosciences, October 2015
|
| DOI | 10.3389/fmolb.2015.00058 |
| Pubmed ID | |
| Authors |
Matthias P. Mayer, Roman Kityk |
| Abstract |
Hsp70s chaperone an amazing number and variety of cellular protein folding processes. Key to their versatility is the recognition of a short degenerate sequence motif, present in practically all polypeptides, and a bidirectional allosteric intramolecular regulation mechanism linking their N-terminal nucleotide binding domain (NBD) and their C-terminal polypeptide substrate binding domain (SBD). Through this interdomain communication ATP binding to the NBD and ATP hydrolysis control the affinity of the SBD for polypeptide substrates and substrate binding to the SBD triggers ATP hydrolysis. Genetic screens for defective variants of Hsp70s and systematic analysis of available structures of the isolated domains revealed some residues involved in allosteric control. Recent elucidation of the crystal structure of the Hsp70 homolog DnaK in the ATP bound open conformation as well as numerous NMR and mutagenesis studies bring us closer to an understanding of the communication between NBD and SBD. In this review we will discuss our current view of the allosteric control mechanism of Hsp70 chaperones. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Czechia | 1 | <1% |
| Switzerland | 1 | <1% |
| Unknown | 103 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 24% |
| Student > Bachelor | 15 | 14% |
| Researcher | 13 | 12% |
| Student > Master | 10 | 10% |
| Student > Doctoral Student | 6 | 6% |
| Other | 14 | 13% |
| Unknown | 22 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 39 | 37% |
| Agricultural and Biological Sciences | 25 | 24% |
| Chemistry | 11 | 10% |
| Physics and Astronomy | 3 | 3% |
| Mathematics | 1 | <1% |
| Other | 2 | 2% |
| Unknown | 24 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 October 2015.
All research outputs
#18,429,163
of 22,830,751 outputs
Outputs from Frontiers in Molecular Biosciences
#1,951
of 3,780 outputs
Outputs of similar age
#203,622
of 283,131 outputs
Outputs of similar age from Frontiers in Molecular Biosciences
#6
of 14 outputs
Altmetric has tracked 22,830,751 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,780 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 283,131 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.